Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R01 Clinical Trial Not Allowed)

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Description

This NIH funding opportunity, led by the National Cancer Institute (NCI) and co-sponsored by the National Human Genome Research Institute (NHGRI), National Institute on Aging (NIA), and National Institute of Dental and Craniofacial Research (NIDCR), invites R01 applications for innovative secondary analysis and integration of existing datasets to advance understanding of cancer risk and related outcomes. The initiative aims to address key scientific questions in cancer research by leveraging and analyzing existing clinical, environmental, surveillance, health services, vital statistics, behavioral, lifestyle, genomic, and molecular data.

Applicants are encouraged to propose new research aims, advanced analytical methods, or novel combinations of datasets that enable exploration of important questions in cancer etiology, risk prediction, prevention, survival, and treatment response. The program is designed to maximize the value of existing data resources and promote cost-effective research that can lead to new insights and hypotheses in cancer control and population sciences.

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Due Dates

• New Applications: June 5, 2025 | October 5, 2025 | February 5, 2026 | June 5, 2026
• Renewal/Resubmission/Revision: July 5, 2025 | November 5, 2025 | March 5, 2026 | July 5, 2026

All applications are due by 5:00 PM local time of the applicant organization. Standard NIH due dates apply; see the NIH due dates page for details.

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Funding Amount

• Direct Costs: Up to $350,000 per year (direct costs), for a maximum project period of 5 years.
• Budget Justification: Requested budgets should reflect the actual needs of the proposed project.
• New Data Generation: Up to 10% of the budget may be allocated for new data generation, but only for validation of key findings.
• No Cost Sharing Required.

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Eligibility

• Eligible Organizations:

  • Public/State and Private Institutions of Higher Education
  • Nonprofits (with or without 501(c)(3) status)
  • For-profit organizations (including small businesses)
  • State, County, City, Township, and Special District Governments
  • Independent School Districts
  • Public Housing Authorities/Indian Housing Authorities
  • Native American tribal governments (federally recognized and other)
  • Faith-based and community-based organizations
  • Regional organizations
  • U.S. Territories and Possessions
  • Non-domestic (non-U.S.) entities (foreign organizations) and foreign components of U.S. organizations

• Eligible Individuals: Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as PD/PI.

• Multiple Applications: Applicant organizations may submit more than one application, provided each is scientifically distinct.

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Application Process

• Mechanism: R01 Research Project Grant (Clinical Trial Not Allowed)
• Submission: Applications must be submitted electronically via Grants.gov using ASSIST, Grants.gov Workspace, or an institutional system-to-system solution.
• Required Registrations: SAM, Grants.gov, eRA Commons (for both organization and PD/PI).
• Application Guide: Follow the NIH Research (R) Instructions and the specific instructions in the funding announcement.
• Data Management and Sharing Plan: Required for all applications.
• Resource Sharing: Awardees are expected to broadly share cleaned/harmonized datasets, software, and analysis tools, consistent with participant consent.

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Additional Information

• Scope: Applications must focus on secondary analysis and/or integration of existing data. Projects may include:

  • Linking and harmonizing multi-level data (genomic, clinical, environmental, behavioral, etc.)
  • Applying innovative analytic or statistical methods
  • Addressing health disparities, cancer survivorship, or healthcare delivery
  • Utilizing public data repositories (e.g., dbGaP, TCGA, SEER, UK Biobank, etc.)

• Non-Responsive Applications: The following are out of scope:

  • Projects proposing new data collection (except for limited validation)
  • Analyses of non-human data only
  • Ongoing data analysis or data maintenance/distribution projects

• Collaborations: Applicants are encouraged to collaborate with data holders and include letters of support for data access as needed.

• Review Criteria: Scientific merit, innovation, feasibility, investigator expertise, and resource sharing plans will be evaluated.

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External Links

• Full Funding Opportunity Announcement (PAR-25-095)
• NIH Application Guide (Forms-H)
• NIH Standard Due Dates
• NCI Cancer Data Resources
• NIH Data Management and Sharing Policy

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Contact Information

For technical assistance with electronic submission, contact the eRA Service Desk or Grants.gov Support.

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