Advanced computational modeling techniques to enable fast screening of RNA biopharmaceutical products

Due: May 1, 2025

$82,764

Description

There has been a recent emergence of RNA biotherapeutics; that is, small RNAs used as drug therapies. Chemical modifications to RNA have been implemented to increase the efficacy of nucleic acid delivery. These modifications affect degradation resistance and render them unrecognizable to the immune system. However, not much is known about how these chemical modifications affect structure-function relationships. We propose to develop robust computational modeling in conjunction with experimental NMR and SAXS measurements to unders...

Award Ceiling$82,764

Eligible Applicants- PostDoc- Early Career Professor

Additional Eligibility Information

Qualified applicants will receive consideration without regard to race, creed, color, age, gender identity, or national origin. Education and Experience Applicants must have earned a Ph.D., Sc.D., M.D., D.V.M., or academically equivalent research doctorate before beginning tenure. The Fellowships Office makes NRC Research Associateship awards at the postdoctoral and senior researcher levels. Postdoctoral Associateships:Applicants must have held the doctorate for less than five years as of the application deadline. Senior Asso...

Funding TypefellowshipCategories of Funding Activity- RNA biotherapeutics- Aptamer drugs- Chemical modifications- Structure-function- Computational modeling- NMR- SAXS

Grantor Contact InformationChristina Bergonzo, christina.bergonzo@nist.gov, (240)314 6333; John P. Marino, john.marino@nist.gov, 240.314.6361Grantor Emailrap@nas.eduOther Grantor InformationThe NRC Research Associateship Programs (RAP) are prestigious postdoctoral and senior research awards designed to provide promising scientists and engineers with high-quality research opportunities at federal laboratories and affiliated institutions. Conducted by the National Academies of Sciences, Engineering, and Medicine's Fellowships Office since 1954, these programs offer a comprehensive research experience through a rigorous selection process. The programs aim to: 1) Offer promising postdoctoral and senior scientists/engineers the chance to pursue self-directed research aligned with sponsoring laboratories' goals, 2) Enhance comprehensive research efforts of participating laboratories, 3) Provide recent doctoral graduates a platform for focused research collaboration with permanent laboratory staff, and 4) Foster professional growth by providing opportunities to gain skills, experience, and connections with leading scientists, ultimately enhancing career prospects in academia, industry, or government research roles. The programs provide mentorship, access to state-of-the-art facilities, and opportunities to influence government policy.

Additional InformationLocation: Material Measurement Laboratory, Biomolecular Measurement Division, Gaithersburg, MD Additional URLs:

https://www.nationalacademies.org/our-work/rap/nrc-research-associateship-programs

https://sites.nationalacademies.org/pga/fellowships/afrl

https://www.nationalacademies.org/documents/embed/link/LF2255DA3DD1C41C0A42D3BEF0989ACAECE3053A6A9B/file/D13308589A09EC935FA87723EB963103495DB429AE7F?noSaveAs=1

https://www.nationalacademies.org/our-work/rap/for-applicants

Supporting Linkhttps://ra.nas.edu/RAPLab10/Opportunity/opportunity.aspx?LabCode=50&ROPCD=506451&RONum=C0395

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Advanced computational modeling techniques to enable fast screening of RNA biopharmaceutical products

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Advanced computational modeling techniques to enable fast screening of RNA biopharmaceutical products

Start finding grants with Atom for

$0 today

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Toward Sequencing and Mapping of RNA Modifications

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