Funder: National Institutes of Health

Due Dates: June 23, 2025 (New, Renewal, Resubmission, Revision) | July 17, 2025 (AIDS) | February 23, 2026 | March 17, 2026 (AIDS) | October 20, 2026 | November 13, 2026 (AIDS)

Funding Amounts: Recommended maximum: $350,000/year direct costs (not a hard cap); up to 3 years recommended, 5 years max; budgets and durations above these require strong justification.

Summary: Supports investigator-initiated mid-phase clinical trials of natural products (botanicals, dietary supplements, probiotics, or standardized nutritional regimens) to determine optimal dosing/formulation or identify responder phenotypes, excluding cancer trials.

Key Information: Preliminary data on bioavailability and target engagement required; efficacy/effectiveness trials and cancer-related studies are not eligible; contact NCCIH program staff before applying, especially for budgets over $500,000/year.