Funder: National Institutes of Health
Due Dates: February 11, 2025 | August 13, 2025 | February 11, 2026 | August 13, 2026 | February 11, 2027 (AIDS - New/Renewal/Resubmission/Revision, as allowed)
Funding Amounts: ~$3M/year for 3–5 awards; budgets not limited but must reflect project needs; max project period 5 years
Summary: Supports innovative research at the intersection of HIV and substance use, aiming to advance prevention, treatment, and cure among people who use drugs.
Key Information: Clinical trials are optional; preliminary data and a clear HIV/substance use nexus are required; aligns with NIH HIV/AIDS Research Priorities.
Description
This NIH funding opportunity supports high-priority research at the intersection of HIV and substance use, with the goal of opening new areas of HIV/AIDS research and/or leading to new avenues for prevention, treatment, and cure among people who use drugs (PWUD). The program welcomes applications from both individual researchers and research teams, spanning basic, epidemiologic, clinical, intervention, and implementation research. All projects must directly address the nexus of HIV and substance use and align with the NIH HIV/AIDS Research Priorities.
Research areas of interest include, but are not limited to:
- Strategies to reduce stigma and improve service utilization for substance use and HIV prevention/care.
- Approaches to address social determinants and disparities in HIV and substance use.
- Interventions to increase uptake of pre-exposure prophylaxis (PrEP) among substance-using populations.
- Integration of HIV testing and care in overdose prevention settings.
- Modeling HIV risk in the context of changing drug use epidemics.
- Biomedical, behavioral, and implementation strategies to improve outcomes for people with or at risk for HIV and substance use disorders (SUDs).
- Research on comorbidities, harm reduction, and optimization of care for aging populations with HIV and SUDs.
Applications must include a detailed research plan, preliminary data, and a clear description of the connection between HIV and substance use.
Due Dates
- Letter of Intent: 30 days prior to the application due date (optional but encouraged)
- Application Deadlines (AIDS-related):
- February 11, 2025
- August 13, 2025
- February 11, 2026
- August 13, 2026
- February 11, 2027
- All applications are due by 5:00 PM local time of the applicant organization.
No late applications will be accepted.
Funding Amount
- Total Funds Available: NIDA intends to commit ~$3 million per year in FY 2025, 2026, and 2027.
- Number of Awards: 3–5 awards per year anticipated.
- Award Budget: No budget cap; budgets must be well-justified and reflect actual project needs.
- Project Period: Up to 5 years.
Eligibility
Eligible applicants include:
- Public/State controlled and private institutions of higher education
- Nonprofits with or without 501(c)(3) status (other than institutions of higher education)
- For-profit organizations (including small businesses)
- State, county, city, township, and special district governments
- Independent school districts
- Native American tribal governments (federally recognized and other)
- Public housing authorities/Indian housing authorities
- Faith-based and community-based organizations
- Regional organizations
- U.S. territories and possessions
- Non-domestic (non-U.S.) entities (foreign organizations) and foreign components of U.S. organizations
Note: Applicant organizations must complete all required registrations (SAM, eRA Commons, Grants.gov, etc.) prior to submission. See the NIH Application Guide for details.
Application Process
- Submission: Applications must be submitted electronically via Grants.gov, NIH ASSIST, or an institutional system-to-system solution.
- Required Components: Follow the NIH Research (R) Instructions and the specific instructions in the funding announcement.
- Letter of Intent: Not required, but recommended to facilitate review planning.
- Clinical Trials: Applications may propose clinical trials but are not required to do so.
- Data Management: All applications must include a Data Management and Sharing Plan.
- Review Criteria: Scientific merit, innovation, rigor, feasibility, investigator expertise, and alignment with NIH HIV/AIDS priorities.
Additional Information
- Alignment: All studies must focus on NIH HIV/AIDS Research Priorities (NOT-OD-20-018).
- Preliminary Data: Required for all applications.
- Special Considerations: NIDA-specific requirements and policies apply; see NIDA Special Considerations.
- Data Resources: Use of NIDA-funded data and specimen resources is strongly encouraged for studies involving human samples.
- Foreign Applicants: Non-U.S. organizations and foreign components are eligible and encouraged to apply.
External Links
Contact Information