Funder: National Institutes of Health
Due Dates: February 5, 2025 (New) | March 5, 2025 (Renewal/Resubmission/Revision) | June 5, 2025 (New) | July 5, 2025 (Renewal/Resubmission/Revision)
Funding Amounts: Application budgets are not limited; typical awards up to $500,000 direct costs/year for up to 5 years.
Summary: Supports development of broadly applicable technologies, tools, and resources to enhance rigor, reproducibility, and translatability of animal models in biomedical research.
Key Information: Clinical trials are not allowed; projects must address multiple organ systems or NIH Institutes/Centers.
Description
This opportunity, offered by the NIH Office of Research Infrastructure Programs (ORIP), funds research projects that develop and implement technologies, tools, and resources to validate animal models and improve the rigor, reproducibility, and translatability of animal research. The goal is to create broadly applicable solutions that address the needs of multiple NIH Institutes and Centers, or that are relevant to diseases and processes affecting multiple organ systems.
Projects must be hypothesis-driven and supported by strong preliminary data. Applications should focus on approaches that have significant impact across a wide range of research areas using animal models, rather than those limited to a single disease or organ system.
Examples of suitable projects include:
- High-efficiency gene editing technologies for animal models
- Nanobodies or functional antibodies for proteins across multiple systems
- Biosensors for multi-parameter monitoring in animal models
- High-resolution imaging tools or atlases for comparative analysis
- Systematic phenotyping technologies at multiple biological scales
- AI/ML tools for integrating multi-omics and phenotypic data
- Technologies to improve humanized animal model development
Projects focused on a single disease, single organ system, or the interests of only one NIH Institute/Center are not responsive.
Due Dates
- February 5, 2025: New applications
- March 5, 2025: Renewal, resubmission, and revision applications (as allowed)
- June 5, 2025: New applications
- July 5, 2025: Renewal, resubmission, and revision applications (as allowed)
All applications are due by 5:00 PM local time of the applicant organization.
Funding Amount
- Budget: Application budgets are not limited but must reflect actual project needs.
- Typical Award: Up to $500,000 in direct costs per year is common; requests at or above this level require prior approval at least 6 weeks before submission.
- Project Period: Up to 5 years.
Eligibility
Eligible applicants include:
- Public and private institutions of higher education
- Nonprofits (with or without 501(c)(3) status)
- For-profit organizations (including small businesses)
- State, county, city, township, and special district governments
- Independent school districts
- Public housing authorities/Indian housing authorities
- Native American tribal governments and organizations (federally recognized and other)
- Faith-based and community-based organizations
- Regional organizations
- U.S. territories and possessions
- Eligible agencies of the federal government
Restrictions:
- Non-domestic (non-U.S.) entities and non-domestic components of U.S. organizations are not eligible to apply.
- Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Application Process
- Submission: Applications must be submitted electronically via ASSIST, Grants.gov Workspace, or an institutional system-to-system solution.
- Instructions: Follow the NIH How to Apply - Application Guide and the specific instructions in the funding announcement (PAR-25-076).
- Key Requirements:
- All PDs/PIs must have an eRA Commons account.
- Organizations must complete all required registrations (SAM, eRA Commons, Grants.gov) before submission.
- Applications requesting $500,000 or more in direct costs in any year must contact a Scientific/Research Contact at least 6 weeks before submission.
- A Data Management and Sharing Plan is required for all applications.
- Clinical trials are not allowed under this opportunity.
Additional Information
- Nonresponsive Projects: Applications focused on a single disease, organ system, or the interests of only one NIH Institute/Center will be withdrawn.
- Contacting Program Staff: Applicants are strongly encouraged to contact ORIP program staff before submission to confirm project responsiveness.
- Review Criteria: Applications will be evaluated for significance, innovation, rigor, feasibility, investigator expertise, and environment, with special attention to the impact on validation, rigor, reproducibility, and translatability of animal models.
External Links
Contact Information