Funder: National Institutes of Health

Due Dates: June 17, 2025 (Renewal/Resubmission/Revision) | October 15, 2025 (Renewal/Resubmission/Revision) | February 13, 2026 (New) | June 15, 2026 (Renewal/Resubmission/Revision) | October 15, 2026 (Renewal/Resubmission/Revision) | February 17, 2027 (New) | June 15, 2027 (Renewal/Resubmission/Revision) | October 15, 2027 (Renewal/Resubmission/Revision)

Funding Amounts: Up to $750,000 direct costs over 3 years; no more than $250,000 direct costs per year; project period up to 3 years.

Summary: Funds pilot hybrid effectiveness-implementation clinical trials to optimize and preliminarily test mental health interventions and implementation strategies in real-world settings.

Key Information: Clinical trial required; foreign and domestic applicants eligible; strong emphasis on mechanism evaluation and community/practice setting relevance.