Quantify the expression of metabolizing enzymes and transporter proteins in lung, eye and skin tissue in relevant animal models and humans

The purpose of this funding opportunity is to systematically quantify the protein levels of potential metabolizing enzymes and transporters in rabbit eye and human eye tissue, human skin tissue, or human lung tissue using most advanced techniques available. Subsequently, the experimental data collected from this study will be implemented into existing modeling platforms to allow for virtual BE assessments locally and systemically for the parent and its pharmacologically active metabolite (for example, prodrugs whe...