Atom | Bioengineering Research Grants (BRG) (R01 Clinical Trial Not Allowed)

Due Dates: June 5, 2025 (New) | July 5, 2025 (Renewal/Resubmission/Revision) | September 7, 2025 (AIDS)

Funding Amounts: No budget limit; project period up to 5 years (R01 mechanism); budgets must reflect actual project needs.

Summary: Supports multidisciplinary bioengineering research integrating life and physical sciences to develop, optimize, and translate innovative tools, methods, or techniques for biomedical problems; clinical trials are not allowed.

Key Information: Applications requesting ≥$500,000 direct costs in any year require prior NIH program contact at least 6 weeks before submission.

Description

This opportunity from the National Institutes of Health (NIH) supports multidisciplinary research projects that apply bioengineering approaches to address significant biomedical problems. The program encourages collaborations between life sciences and physical sciences (including engineering, mathematics, computer science, and related fields) to develop, integrate, optimize, validate, or accelerate the adoption of innovative tools, methods, and techniques for basic, translational, or clinical research and practice.

Projects may be design-directed, developmental, discovery-driven, or hypothesis-driven, and are suitable for small teams using integrative approaches. The focus is on advancing technologies or methods that address unmet needs or specific research/clinical problems, with the potential to enhance understanding of health and disease or improve medical practice. Clinical trials are not permitted under this funding opportunity.

Due Dates

New Applications: June 5, 2025
Renewal/Resubmission/Revision: July 5, 2025
AIDS Applications: September 7, 2025

All applications are due by 5:00 PM local time of the applicant organization. Standard NIH R01 due dates apply; see the NIH due dates page for future cycles.

Funding Amount

Budget: No specific budget limit; budgets must be well-justified and reflect the actual needs of the proposed project.
Project Period: Up to 5 years, depending on the policies of the relevant NIH Institute or Center.
Note: Applications requesting $500,000 or more in direct costs in any year must contact a Scientific/Research Contact at least 6 weeks before submission and follow NIH policy for large-budget applications.

Eligibility

Eligible applicants include:

Public and private institutions of higher education
Nonprofits (with or without 501(c)(3) status)
For-profit organizations (including small businesses)
State, county, city, township, and special district governments
Independent school districts
Public housing authorities/Indian housing authorities
Native American tribal governments and organizations (federally recognized and other)
Faith-based and community-based organizations
Regional organizations
U.S. territories and possessions
Non-domestic (non-U.S.) entities (foreign organizations) and foreign components of U.S. organizations

Individuals: Any qualified individual with the skills, knowledge, and resources necessary to carry out the proposed research as a Program Director/Principal Investigator (PD/PI) may apply.

Application Process

Submission: Applications must be submitted electronically via Grants.gov using the SF424 (R&R) forms.
Required Registrations: Applicant organizations must be registered with SAM, Grants.gov, and eRA Commons. PDs/PIs must have an eRA Commons account.
Application Guide: Follow the NIH SF424 (R&R) Application Guide and the specific instructions in the funding announcement.
Data Management: All applications must include a Data Management and Sharing Plan.
Large Budgets: For applications requesting $500,000 or more in direct costs in any year, contact the relevant NIH program officer at least 6 weeks before submission.

Additional Information

Scope: Projects must clearly serve the mission of at least one participating NIH Institute or Center. Contact the relevant program officer for guidance on fit.
Non-Responsive Applications: Projects that do not involve technology development, or that use unmodified existing technologies for biological/clinical hypotheses, are not responsive.
No Clinical Trials: This opportunity does not support clinical trials.
Review Criteria: Applications are evaluated for significance, investigator(s), innovation, approach, and environment, with additional criteria for multidisciplinary integration and quantitative methods.

External Links

Contact Information

Topic/Institute	Name	Email	Phone
General Grants Info	NIH Grants Information	GrantsInfo@nih.gov	301-945-7573
Cancer Control/Population Sciences	Rao Divi, Ph.D. (NCI)	divir@mail.nih.gov	240-276-6913
Cancer Biology	David Jonathan Miller, Ph.D. (NCI)	david.miller3@nih.gov	240-276-6810
Other Cancer	Miguel R. Ossandon, Ph.D. (NCI)	ossandom@mail.nih.gov	240-276-5714
Child Health	Toyin Ajisafe, Ph.D. (NICHD)	toyin.ajisafe@nih.gov	301-827-9242
Eye Research	Tony Douglas Gover (NEI)	tony.gover@nih.gov	301-529-7370
Dental/Craniofacial	Orlando Lopez, Ph.D. (NIDCR)	orlando.lopez@nih.gov	301-402-4243
Neurological Disorders	Doe Kumsa, Ph.D. (NINDS)	doe.kumsa@nih.gov	301-827-5832
Musculoskeletal/Skin	Xincheng (Ted) Zheng, M.D., Ph.D. (NIAMS)	zhengx4@mail.nih.gov	301-594-4953
Deafness/Communication	Nancy Freeman, Ph.D. (NIDCD)	freemann@mail.nih.gov	301-402-3458

For additional contacts (peer review, financial/grants management), see the full announcement Section VII.