PHS 2024-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)

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Description

This opportunity, issued by the National Institutes of Health (NIH), invites eligible US small businesses to apply for Small Business Technology Transfer (STTR) grants (R41/R42) to support research and development of innovative technologies with strong commercialization potential in health, medicine, and related fields. The program requires a formal collaboration between a small business and a US research institution. Clinical trials are not permitted under this solicitation.

The STTR program aims to foster technology transfer through cooperative R&D between small businesses and research institutions, accelerating the translation of scientific discoveries into products and services that improve public health. Projects must align with the research missions of participating NIH Institutes and Centers.

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Due Dates

• September 5, 2024
• January 5, 2025
• April 5, 2025
• September 5, 2025

All applications are due by 5:00 PM local time of the applicant organization. The program expires September 6, 2025.

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Funding Amount

• Phase I: Up to $306,872 total costs for up to 1 year
• Phase II: Up to $2,045,816 total costs for up to 2 years
• Phase IIB (if applicable): Budget limits set by participating NIH Institutes/Centers
• Higher budgets: May be allowed for specific topics with NIH approval (see list of approved topics for budget waivers)

Applicants are encouraged to propose budgets that are reasonable and appropriate for the proposed work. Contact program officials if planning to exceed standard limits.

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Eligibility

• Applicant: Only United States small business concerns (SBCs) are eligible.
  • Organized for profit, with a place of business in the US.
  • At least 50% US citizen or permanent resident ownership.
  • No more than 500 employees (including affiliates).
  • Must partner with a US nonprofit research institution (e.g., university, federal lab).
  • Small businesses majority-owned by multiple venture capital, hedge fund, or private equity firms are not eligible for STTR.
• Foreign organizations: Not eligible. Foreign components may be allowed if justified.
• Principal Investigator: May be employed by either the small business or the research institution, but must commit at least 10% effort and have a formal relationship with the small business.
• Multiple applications: Allowed if each is scientifically distinct.

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Application Process

• Submission: Applications must be submitted electronically via Grants.gov, NIH ASSIST, or an institutional system-to-system solution.
• Required registrations:
  • SAM.gov
  • SBA Company Registry
  • eRA Commons
  • Grants.gov
• Instructions: Follow the NIH SBIR/STTR Application Guide and the specific requirements in the funding announcement.
• Project types: New (Phase I, Fast-Track), Renewal (Phase II, Phase IIB), Resubmission, Revision.
• No clinical trials: Applications proposing clinical trials are not allowed under this announcement; use PA-24-248 for clinical trial proposals.

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Additional Information

• Research topics: Projects must align with the missions of participating NIH Institutes and Centers. See the SBIR/STTR Program Descriptions and Research Topics for NIH, CDC, and FDA.
• Collaboration: At least 40% of the work must be performed by the small business, and at least 30% by the partnering research institution.
• Performance benchmarks: Applicants with significant prior SBIR/STTR funding must meet transition and commercialization benchmarks.
• Data management: All applicants must address data management and sharing, but SBIR/STTR awardees may retain data rights for up to 20 years.
• Disclosure: Applicants must disclose foreign affiliations and relationships as required by NIH policy.

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External Links

• NIH Funding Announcement (PA-24-247)
• Grants.gov Opportunity Page
• SBIR/STTR Program Descriptions and Research Topics
• NIH SBIR/STTR Applicant Resources
• NIH Application Guide
• NIH List of Institutes and Centers

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Contact Information

For additional contacts, see Section VII of the full announcement.

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