Creating Computational Techniques to Investigate the Ensemble Structures of Flexible Proteins In Combination with Neutron Scattering Data

Due: May 1, 2025

$82,764

Description

Flexible proteins, such as monoclonal antibodies, are widely used platforms for treating disease. However, the complexity of their structure makes generating actionable predictions of critical quality attributes (CQAs) difficult. True advancement in making these predictions requires a shift in understanding the problem, from a single-structure representation to using ensembles of structures as the best predictors of experimental data. This requires a bottom-up reimagining of many different methodological assumptions, that are cur...

Award Ceiling$82,764

Eligible Applicants- PostDoc

Additional Eligibility Information

Qualified applicants will receive consideration without regard to race, creed, color, age, gender identity, or national origin. Education and Experience Applicants must have earned a Ph.D., Sc.D., M.D., D.V.M., or academically equivalent research doctorate before beginning tenure. The Fellowships Office makes NRC Research Associateship awards at the postdoctoral and senior researcher levels. Postdoctoral Associateships:Applicants must have held the doctorate for less than five years as of the application deadline. Senior Asso...

Funding TypefellowshipCategories of Funding Activity- biotechnology- drug products- neutron scattering- ensemble structures- MD simulations- computation

Grantor Contact InformationChristina Bergonzo, Email: christina.bergonzo@nist.gov, Phone: (240)314-6333; Yun Liu, Email: yun.liu@nist.gov, Phone: (301)975-6235Grantor Emailrap@nas.eduOther Grantor InformationThe NRC Research Associateship Programs (RAP) are prestigious postdoctoral and senior research awards designed to provide promising scientists and engineers with high-quality research opportunities at federal laboratories and affiliated institutions. Conducted by the National Academies of Sciences, Engineering, and Medicine's Fellowships Office since 1954, these programs offer a comprehensive research experience through a rigorous selection process. The programs aim to: 1) Offer promising postdoctoral and senior scientists/engineers the chance to pursue self-directed research aligned with sponsoring laboratories' goals, 2) Enhance comprehensive research efforts of participating laboratories, 3) Provide recent doctoral graduates a platform for focused research collaboration with permanent laboratory staff, and 4) Foster professional growth by providing opportunities to gain skills, experience, and connections with leading scientists, ultimately enhancing career prospects in academia, industry, or government research roles. The programs provide mentorship, access to state-of-the-art facilities, and opportunities to influence government policy.

Additional InformationLocation: Gaithersburg, MD Additional URLs:

https://www.nationalacademies.org/our-work/rap/nrc-research-associateship-programs

https://sites.nationalacademies.org/pga/fellowships/afrl

https://www.nationalacademies.org/documents/embed/link/LF2255DA3DD1C41C0A42D3BEF0989ACAECE3053A6A9B/file/D13308589A09EC935FA87723EB963103495DB429AE7F?noSaveAs=1

https://www.nationalacademies.org/our-work/rap/for-applicants

Supporting Linkhttps://ra.nas.edu/RAPLab10/Opportunity/opportunity.aspx?LabCode=50&ROPCD=506451&RONum=C0789

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