After the passage of the Affordable Care Act, health reform entered a critical new phase. The health system has been strained by increasing demand and unsustainable costs. Too often, care decisions do not align with patient goals or evidence of effectiveness, and Americans experience untenable disparities in health and access to care. At the same time, new technologies and big data are spurring advances in medical science and the practice of care, including precision medicine. Patients are increasingly empowered to take an active...