Funder: Advanced Research Projects Agency for Health
Due Dates: Submissions under review; new submissions are no longer accepted
Funding Amounts: Flexible funding with milestone-driven execution
Summary: Supports development of a single, rapid, low-cost radiotherapy treatment effective against localized, metastatic, and radiotherapy-resistant cancers.
Description
One Comprehensive Universal Radiotherapy for Everyone (1-CURE) is an Advanced Research Projects Agency for Health (ARPA-H) program seeking to replace prolonged cancer treatment with one affordable, accessible, curative intervention. It targets all cancer types, including localized tumors, metastatic disease, and cancers resistant to conventional radiotherapy, with the goals of improving survival and reducing the financial burden on patients, families, and the healthcare system.
The program combines multifunctional smart radiotherapy biomaterials with an Abscopal Treatment Planning System. The biomaterials support precise image-guided targeting and sustained delivery of immunoadjuvants. The planning system integrates those materials with ultra-high dose rate FLASH radiotherapy to optimize immune responses against tumors throughout the body. The intended treatment would eliminate local and metastatic tumors and prevent recurrence.
