[Jerome Lejeune Foundation](https://www.research.fondationlejeune.org/call-for-projets/)

July 1, 2025 – September 5, 2025 (Autumn Call)

Pilot grants: up to €50,000 over 2 years | Advanced grants: up to €80,000 over 2 years

Supports innovative research on Trisomy 21, including fundamental, translational, clinical, epidemiological, and neuropsychological studies.

Use of human embryonic/fetal tissues or materials from abortion, IVF, or cloning is strictly prohibited.

--- ## Description The Jerome Lejeune Foundation's 2025 Autumn Call funds research projects exclusively focused on Trisomy 21 (Down syndrome). The program supports a wide range of research, including fundamental studies on disease mechanisms, translational research with potential clinical impact, early-phase clinical and ancillary studies, epidemiological investigations, and the development or application of neuropsychological techniques. The aim is to advance understanding, diagnosis, therapy, and rehabilitation for individuals with Trisomy 21. Projects must not use human embryonic or fetal tissues, or materials obtained via abortion, IVF, or cloning. --- ## Due Dates - Application window: July 1, 2025 – September 5, 2025 --- ## Funding Amount - **Pilot or exploratory grants:** Up to €50,000 over 2 years (for early-stage or complementary projects) - **Advanced grants:** Up to €80,000 over 2 years (for larger, breakthrough projects with substantial preliminary data) - Number of funded projects depends on the annual budget allocated by the Foundation. --- ## Eligibility - Principal investigators of any nationality are eligible. - Applicants must hold a long-term appointment at an academic institution for the full project duration. - Proposals must focus exclusively on Trisomy 21. - Applicants must have an excellent track record and submit a high-quality proposal. - Strict prohibition on the use of human embryonic/fetal tissues or materials from abortion, IVF, or cloning. --- ## Application Process - All applications must be submitted through the [online application system](https://funding.fondationlejeune.org/home). - Required documents: - [Application Guidelines (PDF)](https://www.research.fondationlejeune.org/wp-content/uploads/2025/01/FJL-Grants-Application-Guidelines-2025A.pdf) - [Project file template (DOCX)](https://www.research.fondationlejeune.org/wp-content/uploads/2024/12/Project-file-template_FJL-Grants-Application_2025A-Spring-call.docx) - [Certificate of compliance with the guidelines (PDF)](https://www.research.fondationlejeune.org/wp-content/uploads/2025/01/Certificate-of-compliance-with-the-guidelines-2025A.pdf) - Proposals are evaluated by the Foundation's Scientific Advisory Board and external reviewers based on scientific excellence, novelty, feasibility, and potential clinical or therapeutic impact. - Final funding decisions are made by the Board of Directors. --- ## Additional Information - The Autumn Call is exclusively for Trisomy 21 research; the Spring Call funds other genetic intellectual disabilities (excluding Trisomy 21). - Since 1997, the Foundation has funded over 850 projects totaling more than €28 million. - See examples of [previously funded projects](https://www.research.fondationlejeune.org/call-for-projets/funded-projects-2024/). --- ## External Links - [Jerome Lejeune Foundation – Call for Projects](https://www.research.fondationlejeune.org/call-for-projets/) - [Online Application Portal](https://funding.fondationlejeune.org/home) - [Application Guidelines PDF](https://www.research.fondationlejeune.org/wp-content/uploads/2025/01/FJL-Grants-Application-Guidelines-2025A.pdf) - [Project File Template DOCX](https://www.research.fondationlejeune.org/wp-content/uploads/2024/12/Project-file-template_FJL-Grants-Application_2025A-Spring-call.docx) - [Certificate of Compliance PDF](https://www.research.fondationlejeune.org/wp-content/uploads/2025/01/Certificate-of-compliance-with-the-guidelines-2025A.pdf) - [Funded Projects 2024](https://www.research.fondationlejeune.org/call-for-projets/funded-projects-2024/) --- ## Contact Information | Contact Person / Office | Email | Phone | |----------------------------------------------|-----------------------------------------------|-------------------| | Conseil Scientifique – Fondation Jérôme Lejeune | [funding@fondationlejeune.org](mailto:funding@fondationlejeune.org) | +33 (0)1 5658 5638 | For general foundation information: [About the Foundation](https://www.lejeunefoundation.org/about-us) [Main Foundation Website](https://www.lejeunefoundation.org/)

2025 Autumn Call - Jerome Lejeune Foundation

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