[Cures Within Reach](https://www.cureswithinreach.org)

June 26, 2026: Letter of Intent deadline

Up to $100,000 per project (includes 10% institutional match); additional funds may be available for community engagement.

Supports global, investigator-initiated Phase I/IIA clinical trials that use AI-driven approaches to repurpose already approved therapies for any disease.

--- ## Description This funding opportunity supports investigator-initiated, proof-of-concept Phase I or IIA clinical trials that seek to validate artificial intelligence (AI)-driven drug repurposing in any disease area. The program is designed to accelerate the clinical validation of AI model predictions by funding trials that use already approved drugs, biologics, or eligible cellular/gene therapies. Projects must be led by principal investigators from nonprofit academic or research institutions anywhere in the world. All proposals must include AI-generated data as part of the required preclinical support. There is a preference for rare diseases, off-patent therapies, and the use of openly accessible or nonprofit/government-developed AI models. --- ## Due Dates - June 26, 2026: Letter of Intent deadline --- ## Funding Amount - Maximum budget per project: **up to $100,000** (includes a required 10% institutional match) - Additional funds may be available for community engagement activities --- ## Eligibility - Principal Investigator must be affiliated with a nonprofit academic or research institution (global eligibility). - Eligible projects are Phase I or IIA clinical trials in any disease area. - The therapy to be tested must be an already approved drug, biologic, or eligible cellular/gene therapy. - Submission must incorporate AI-generated data as part of preclinical support for the trial. - Preference is given to: - Rare disease indications - Off-patent drugs/biologics - Openly accessible AI models or those developed by nonprofits/government entities --- ## Application Process - Submit a Letter of Intent (LOI) by June 26, 2026. - Applications are submitted via [ProposalCentral](https://proposalcentral.com/). - If you are a new user, create an account before submission. - Review the full RFP and attend an optional info session for further details: - [AI Validation RFP Info Sessions PDF](https://www.cureswithinreach.org/wp-content/uploads/2026/04/CWR-2026-AI-Validation-RFP-info-sessions.pdf) - For more information and to start your LOI, visit [Cures Within Reach Funding Opportunities](https://www.cureswithinreach.org/programs/funding-opportunities-rfps/). --- ## Additional Information - The list of potential AI model resources is available and updated during the LOI window ([Potential AI Model Resources PDF](https://www.dropbox.com/scl/fi/byk7713ha2c9m7vsq98ab/Potential-AI-Model-Resources-for-CWR-2026-RFP.pdf?rlkey=m4gd4121vum0pta4uyy0fnx2v&st=vt4jplow&dl=0)), but use of models outside this list is permitted. - Questions about eligibility or the application process can be directed to the funder. --- ## External Links - [Cures Within Reach Funding Opportunities / RFPs](https://www.cureswithinreach.org/programs/funding-opportunities-rfps/) - [AI Validation Program Overview](https://www.cureswithinreach.org/programs/ai-validation/) - [2026 AI Validation RFP Info Sessions PDF](https://www.cureswithinreach.org/wp-content/uploads/2026/04/CWR-2026-AI-Validation-RFP-info-sessions.pdf) - [Potential AI Model Resources for CWR 2026 RFP (PDF)](https://www.dropbox.com/scl/fi/byk7713ha2c9m7vsq98ab/Potential-AI-Model-Resources-for-CWR-2026-RFP.pdf?rlkey=m4gd4121vum0pta4uyy0fnx2v&st=vt4jplow&dl=0) - [ProposalCentral Application Portal](https://proposalcentral.com/) --- ## Contact Information | Purpose | Contact | |--------------------------|-------------------------------------------| | General Inquiries | [info@cureswithinreach.org](mailto:info@cureswithinreach.org) | | Research/RFP Questions | [research@cureswithinreach.org](mailto:research@cureswithinreach.org) | | Online Contact Form | [Contact Us](https://www.cureswithinreach.org/about-us-repurposing-research-leader/contact-us-get-involved-in-repurposing-research/) |

2026 Funding Opportunity RFP for Clinical Trials to Validate AI-Driven Drug Repurposing

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