Structure and stability of lipid-based drug delivery platforms

Lipid-based assemblies, like liposomes, lipid nanoparticles (LNPs), and emulsions, are widely used to encapsulate and protect therapeutic molecules. Several lipid-based drug delivery platforms are used clinically as vaccines and to treat diseases ranging from fungal infections to cancer. However, each formulation must be carefully optimized. Encapsulation and retention of drug molecules depends on the lipid composition, buffer components, and processing conditions while the uptake and delivery performance depend on the size, surf...