Protein Aggregation
Protein aggregation during biomanufacturing will be studied by controlling environmental factors and measuring adsorption to determine formation mechanisms.
This grant is no longer accepting proposals
NRC Research Associateship Programs has archived this opportunity.
Funder: NRC Research Associateship Programs
Due Dates: February 1, 2025 | May 1, 2025 | August 1, 2025 | November 1, 2025
Funding Amounts: $82,764 stipend plus $3,000 travel allowance; typical appointment duration 2 years.
Summary: Supports postdoctoral research on protein aggregation mechanisms at NIST by controlling environmental factors and performing in-situ adsorption and particle characterization measurements.
Key Information: Open to U.S. citizens with a doctoral degree earned within the last 5 years; requires contacting a Research Adviser prior to application.
Description
This fellowship opportunity, offered through the NRC Research Associateship Programs at the National Institute of Standards and Technology (NIST), focuses on the study of protein aggregation during biomanufacturing. Protein aggregation is driven by microscopic fluid dynamics at surfaces, which can lead to irreversible aggregation—a significant concern in biomanufacturing processes.
The research aims to control key environmental parameters such as temperature, interface chemistry, and shear rate to decouple the complex interplay between thermodynamics, interfacial adsorption, and hydrodynamic deformation and transport. The project involves in-situ measurements of protein adsorption (both structure and amount) and particle characterization to elucidate the mechanisms of protein aggregate formation.
Key research areas include protein solutions, monoclonal antibodies, interfacial adsorption, optical microscopy, microfluidics, and neutron scattering.
