Expanding the Opioids System Model to more comprehensively incorporate fentanyl, stimulants use, polysubstance use and associated outcomes.
This grant expands an FDA model to include fentanyl, stimulants, and polysubstance use to better understand and address opioid overdose deaths and evaluate harm reduction strategies.
This grant is no longer accepting proposals
Food and Drug Administration has archived this opportunity.
Funder: Food and Drug Administration (FDA)
Due Dates: Archiving forecast (no current open deadline)
Funding Amounts: Cooperative Agreement; specific award amounts not listed
Summary: Expands an FDA system-dynamic model to incorporate fentanyl, stimulants, and polysubstance use to better understand opioid overdose deaths and evaluate harm reduction strategies.
Key Information: Focus on modeling opioid overdose deaths involving stimulant and polysubstance users; includes harm reduction and mental health factors.
Description
This grant opportunity supports the expansion of a quantitative system-dynamic model of the opioid crisis developed by the FDA’s Office of Prescription Drug Promotion (OPSA). The model aims to help the FDA understand the complex, interconnected mechanisms driving the opioid epidemic and to assess the potential impacts of policy actions.
The current project builds on previous cooperative agreements awarded to Harvard/Mass General to develop initial versions of the model. The expansion focuses on more comprehensively incorporating fentanyl, stimulant use, polysubstance use, and their interactive effects on opioid use, misuse, addiction, treatment, and related outcomes.
A key emphasis is on modeling the increasing number of opioid overdose deaths involving individuals who primarily use stimulants or multiple substances, reflecting an emerging and critical aspect of the opioid crisis. The research will also quantify the effects of harm reduction strategies such as naloxone distribution and increased availability of treatment for Opioid Use Disorder (OUD) on overdoses involving fentanyl and polysubstance use.
Additionally, the project seeks to identify and integrate feasible aspects of mental health into the model to better capture the broader societal and health outcomes associated with opioid and polysubstance use.
