ClinGen Genomic Curation Expert Panels (U24 Clinical Trial Not Allowed)
Limited submission
This grant funds expert panels to select and determine the clinical significance of genes and genomic variants for diagnosis and treatment of high-priority diseases, using standardized procedures and tools provided by NIH.
This grant is no longer accepting proposals
National Institutes of Health has archived this opportunity.
Funder: National Institutes of Health
Due Dates: May 25, 2025 (Renewal/Resubmission/Revision)
Funding Amounts: Up to $220,000 direct costs per year; maximum project period 3 years; cooperative agreement (U24)
Summary: Funds expert panels to select and determine the clinical significance of genes and genomic variants for high-priority diseases using standardized NIH procedures and tools.
Key Information: Clinical trials are not allowed; limited submission—see eligibility and application details.
Description
This opportunity supports the formation of Genomic Curation Expert Panels to systematically select and assess the clinical significance of genes and genomic variants associated with diseases or conditions of high priority to participating NIH Institutes and Centers. Funded panels will use the NHGRI Clinical Genomics Resource (ClinGen) and NCBI ClinVar infrastructure, procedures, and tools to standardize variant annotation and interpretation, and to implement evidence-based, expert consensus assertions for use in precision medicine and research.
Panels are expected to address diseases or conditions relevant to the missions of participating NIH Institutes, including but not limited to cancer, rare diseases, neurological, mental health, musculoskeletal, skin, vision, hearing, and reproductive disorders. The initiative aims to improve the clinical utility of genetic testing by reducing the number of variants of unknown significance and supporting evidence-based clinical decision-making.
