Mechanistic Research on Neuromodulation for Substance Use Disorders Treatment (R01 Clinical Trial Optional)
Research on using brain stimulation to treat substance use disorders, focusing on identifying targets and understanding how it affects the brain and behavior. Requires a plan for diverse perspectives.
This grant is no longer accepting proposals
National Institutes of Health has archived this opportunity.
Funder: National Institutes of Health
Due Dates: August 14, 2025 (New/Renewal/Resubmission/Revision) | January 16, 2026 (New/Renewal/Resubmission/Revision) | August 14, 2026 (New/Renewal/Resubmission/Revision)
Funding Amounts: $1.5M/year (total for all awards); up to 6 awards; budgets not limited but must reflect project needs; max project period 5 years.
Summary: Supports clinical research to identify and validate novel non-invasive brain stimulation targets and mechanistic responses for substance use disorder treatment.
Key Information: Requires a Plan for Enhancing Diverse Perspectives (PEDP); applications without a PEDP will be withdrawn.
Description
This opportunity, offered by the National Institute on Drug Abuse (NIDA) at NIH, seeks clinical research projects that will identify and validate novel targets for non-invasive brain stimulation (NIBS) in the treatment of substance use disorders (SUD). The focus is on understanding the neurobiological, cognitive, and behavioral responses to NIBS that precede clinical outcomes such as reduced craving or drug use. The ultimate goal is to advance mechanistic understanding of SUD and inform future clinical trial design by identifying new stimulation targets and proximal efficacy metrics.
Projects may use modalities such as transcranial magnetic stimulation (TMS), transcranial direct or alternating current stimulation, or other non-invasive approaches. Studies should go beyond preselected cortical targets and clinical endpoints, aiming to uncover new brain circuits and intermediate markers relevant to SUD.
Note: A Plan for Enhancing Diverse Perspectives (PEDP) is required and will be evaluated during peer review. Applications lacking a PEDP will be considered incomplete and withdrawn.
