Funder: National Institutes of Health
Due Dates: June 15, 2025 (Letter of Intent) | July 15, 2025 (Application) | August 18, 2025 (AIDS) | January 15, 2026 (Application) | April 17, 2026 (AIDS) | July 15, 2026 (Application) | August 18, 2026 (AIDS)
Funding Amounts: Up to $500,000 total cost/year (Phase I, up to 2 years) | Up to $1,500,000 total cost/year (Phase II, up to 3 years); max 5 years total
Summary: Supports U.S. small businesses in advancing small molecule drug discovery and development for nervous system disorders, from hit optimization through IND-enabling studies and phase I clinical testing, with NIH collaboration and IP retention.
Key Information: Applicants must be U.S. small businesses; projects can enter at either discovery or development stage; clinical trial optional (up to phase I only).