Small Business Transition Grant for New Entrepreneurs (R43/R44 Clinical Trial Required)
This grant aims to support new entrepreneurs in small businesses by developing their entrepreneurial skills while conducting research under their direction.
This grant is no longer accepting proposals
National Institutes of Health has archived this opportunity.
Funder: National Institutes of Health (NIH)
Due Dates: November 17, 2025 (Full application)
Funding Amounts: Typical SBIR Phase I: up to $295,924 for 6-12 months; Phase II: up to $1,972,828 for up to 2 years; actual amounts may vary by Institute and project.
Summary: Supports new entrepreneurs in small businesses through both clinical trial research and targeted entrepreneurial training to advance health-related technologies.
Key Information: Clinical trial required; only U.S. small businesses are eligible; non-domestic entities cannot apply.
Description
This NIH program supports U.S. small business concerns (SBCs) in employing and developing early-career researchers as entrepreneurial Program Directors/Principal Investigators (PDs/PIs). The grant aims to simultaneously foster entrepreneurial development and support clinical trial research and development under the direction of these new entrepreneurs. The initiative is designed for scientists and professionals with strong technical backgrounds but limited entrepreneurial and independent research leadership experience. Awardees will receive entrepreneurial training, mentoring, and career development while working within a small business to develop technologies and products that align with NIH’s mission to improve health and save lives.
