Towards a Better Understanding of the Neurological Effects of Infection-Associated Chronic Illnesses (R21 - Clinical Trial Optional)
Research grant aims to study neurological effects of infection-related chronic illnesses, including COVID-19 aftermath and similar conditions, seeking pathways for effective treatments.
This grant is no longer accepting proposals
National Institutes of Health has archived this opportunity.
Funder: National Institutes of Health
Due Dates: June 16, 2025 (New) | July 16, 2025 (Renewal/Resubmission/Revision) | October 16, 2025 (New) | November 16, 2025 (Renewal/Resubmission/Revision) | Letters of Intent: May 17, 2025 | September 16, 2025
Funding Amounts: Up to $275,000 direct costs over 2 years; no more than $200,000 in any single year; project period max 2 years.
Summary: Supports exploratory research on neurological and/or mental health effects of infection-associated chronic illnesses, including Long COVID, ME/CFS, POTS, and related conditions.
Key Information: Clinical trial optional; mechanistic focus required; foreign and domestic applicants eligible.
Description
This NIH funding opportunity (R21, Clinical Trial Optional) solicits applications for exploratory and developmental research projects investigating the neurological and/or mental health manifestations of infection-associated chronic illnesses. The scope includes, but is not limited to, post-acute sequelae of COVID-19 (Neuro-PASC/Long COVID), post-treatment Lyme Disease, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), postural orthostatic tachycardia syndrome (POTS), post-viral fatigue syndromes, and other chronic illnesses with a suspected infectious trigger.
Projects may focus on a single condition or investigate common mechanisms across multiple conditions. Both clinical and preclinical studies are encouraged, provided they address mechanistic pathways relevant to post-infectious etiology. Mechanistic clinical trials and basic experimental studies in humans (BESH) are within scope. Preclinical studies using animal, cell culture, or human tissue models are also encouraged.
