Development of Resources and Technologies for Enhancing Rigor, Reproducibility, and Translatability of Animal Models in Biomedical Research (R01 Clinical Trial Not Allowed)
Developing technologies to enhance rigor, reproducibility, and translatability of animal models in biomedical research by creating broadly applicable tools and resources aligning with NIH mission.
This grant is no longer accepting proposals
National Institutes of Health has archived this opportunity.
Funder: National Institutes of Health
Due Dates: February 5, 2025 (New) | March 5, 2025 (Renewal/Resubmission/Revision) | June 5, 2025 (New) | July 5, 2025 (Renewal/Resubmission/Revision)
Funding Amounts: Application budgets are not limited; typical awards up to $500,000 direct costs/year for up to 5 years.
Summary: Supports development of broadly applicable technologies, tools, and resources to enhance rigor, reproducibility, and translatability of animal models in biomedical research.
Key Information: Clinical trials are not allowed; projects must address multiple organ systems or NIH Institutes/Centers.
Description
This opportunity, offered by the NIH Office of Research Infrastructure Programs (ORIP), funds research projects that develop and implement technologies, tools, and resources to validate animal models and improve the rigor, reproducibility, and translatability of animal research. The goal is to create broadly applicable solutions that address the needs of multiple NIH Institutes and Centers, or that are relevant to diseases and processes affecting multiple organ systems.
Projects must be hypothesis-driven and supported by strong preliminary data. Applications should focus on approaches that have significant impact across a wide range of research areas using animal models, rather than those limited to a single disease or organ system.
Examples of suitable projects include:
- High-efficiency gene editing technologies for animal models
- Nanobodies or functional antibodies for proteins across multiple systems
- Biosensors for multi-parameter monitoring in animal models
- High-resolution imaging tools or atlases for comparative analysis
- Systematic phenotyping technologies at multiple biological scales
- AI/ML tools for integrating multi-omics and phenotypic data
- Technologies to improve humanized animal model development
Projects focused on a single disease, single organ system, or the interests of only one NIH Institute/Center are not responsive.
