Funder: National Institutes of Health

Due Dates: June 5, 2025 (New) | July 5, 2025 (Renewal/Resubmission/Revision) | October 5, 2025 (New) | November 5, 2025 (Renewal/Resubmission/Revision) | February 5, 2026 (New) | March 5, 2026 (Renewal/Resubmission/Revision) | June 5, 2026 (New) | July 5, 2026 (Renewal/Resubmission/Revision) | October 5, 2026 (New) | November 5, 2026 (Renewal/Resubmission/Revision) | February 5, 2027 (New) | March 5, 2027 (Renewal/Resubmission/Revision) | June 5, 2027 (New) | July 5, 2027 (Renewal/Resubmission/Revision) | October 5, 2027 (New) | November 5, 2027 (Renewal/Resubmission/Revision)

Funding Amounts: Up to $499,999 direct costs/year, max 5 years; modular or detailed budget allowed; number of awards depends on NIH appropriations and merit.

Summary: Supports screening and functional validation of genomic variants associated with human congenital anomalies using in-silico, in vitro, and animal models.

Key Information: Clinical trials are not allowed; foreign organizations are eligible; projects must validate function in animal models (not just in vitro).