Advancing Research to Understand Congenital Malformations (R01 Clinical Trial Not Allowed)
Funding available for innovative research on genetic and environmental factors in causing birth defects using animal models and human-focused approaches.
This grant is no longer accepting proposals
National Institutes of Health has archived this opportunity.
Funder: National Institutes of Health
Due Dates: June 5, 2025 (New) | July 5, 2025 (Renewal/Resubmission/Revision) | September 8, 2025 (Expiration)
Funding Amounts: Up to $499,999 direct costs per year, for a maximum project period of 5 years.
Summary: Supports innovative research on the mechanisms underlying structural birth defects, using animal models and human translational/clinical approaches; clinical trials are not allowed.
Key Information: Applications must combine basic and clinical/translational approaches; traditional epidemiology or projects focused solely on clinical aspects are not responsive.
Description
This opportunity supports research to advance understanding of the mechanisms that underlie the formation of structural birth defects. The program encourages projects that integrate animal models with human translational or clinical approaches, leveraging advances in genetics, genomics, proteomics, metabolomics, synthetic biology, and developmental biology. The ultimate goal is to identify genetic, epigenetic, and environmental factors (including gene-environment interactions) that contribute to the formation, susceptibility, and variability of structural birth defects in human populations.
Projects should aim to develop or apply innovative methods to identify and characterize the causes of congenital anomalies, with the long-term objective of informing screening, prevention, and treatment strategies. Interdisciplinary teams involving clinicians, genetic epidemiologists, and basic scientists are encouraged but not required.
Note: This opportunity does not support clinical trials.
