Funder: National Institutes of Health
Due Dates: February 5, 2027 (New) | March 5, 2027 (Renewal/resubmission/revision) | June 5, 2027 (New) | July 5, 2027 (Renewal/resubmission/revision) | October 5, 2027 (New) | November 5, 2027 (Renewal/resubmission/revision) | January 7, 2028 (Closing date)
Funding Amounts: No budget cap; requests must reflect actual project needs, for up to 5 years.
Summary: Supports engineering development of novel or substantially improved brain stimulation devices for treating mental health disorders.
Key Information: Clinical trials are not allowed; multidisciplinary investigator teams are required.
Description
The National Institute of Mental Health (NIMH) administers this R01 program to develop next-generation brain stimulation devices for mental health disorders. It supports novel devices and significant hardware or software enhancements to existing FDA-approved or cleared devices. Priorities include greater spatial and temporal precision, deeper stimulation, multi-focal delivery, and closed-loop approaches. Novel devices should move beyond existing electrical and magnetic stimulation techniques.
Projects should emphasize engineering development, bench testing, and preclinical validation rather than hypothesis-driven studies using devices. Both invasive and non-invasive technologies are eligible. Animal testing and limited human testing that does not constitute a clinical trial may support initial proof of concept, but tools must be designed for human use. Industry partnerships are encouraged.
