The purpose of this notice is to inform the research community that the National Institute of Nursing Research (NINR) intends to publish a notice of funding opportunity (NOFO), NINR Areas of Emphasis for Research to Optimize Health for All (R21 Clinical Trial Optional), a re-issuance of PAR-22-231. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the R21 activity code. Details of the planned NOFO are provided below.