Funder: National Institutes of Health

Due Dates: June 17, 2025 (New/Renewal/Resubmission/Revision) | October 15, 2025 | February 13, 2026 | June 15, 2026 | October 15, 2026 | February 17, 2027 | June 15, 2027 | October 15, 2027

Funding Amounts: No budget cap; project period up to 5 years; $27M total across this and companion NOFOs in FY26.

Summary: Funds large-scale, multisite clinical trials of mental health interventions in real-world settings to improve access, quality, and outcomes.

Key Information: Clinical trial required; hybrid effectiveness-implementation design mandatory; foreign and domestic applicants eligible.