Atom | Confirmatory Efficacy Clinical Trials of Non-Pharmacological and Pharmacological Interventions for Mental Disorders (R01 Clinical Trial Required)

Funder: National Institutes of Health

Funding Amounts: No budget cap; budgets must reflect actual project needs. Maximum project period: 5 years. NIH intends to commit $27M in FY 2026 across this and companion NOFOs.

Summary: Supports confirmatory efficacy clinical trials of non-pharmacological and selected pharmacological interventions for mental disorders in adults and children, emphasizing experimental therapeutics and unmet therapeutic needs.

Key Information: Clinical trial required; strong preliminary evidence of target engagement and efficacy signal needed; limited to confirmatory efficacy stage (not initial development or effectiveness trials).

Confirmatory Efficacy Clinical Trials of Non-Pharmacological and Pharmacological Interventions for Mental Disorders (R01 Clinical Trial Required)

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