Funder: National Institutes of Health

Due Dates: June 17, 2025 | October 17, 2025 | February 19, 2026 | June 15, 2026 | October 15, 2026 | February 17, 2027 | June 15, 2027 | October 15, 2027

Funding Amounts: No budget cap; project period up to 3 years; budgets must reflect actual project needs. Total NIMH commitment (all related NOFOs): $27M in FY 2026.

Summary: Supports pilot clinical trials to develop and test innovative psychosocial interventions for mental disorders, emphasizing experimental therapeutics and target engagement.

Key Information: Clinical trial required; only applications proposing novel psychosocial interventions or targets are responsive; foreign and domestic applicants eligible.