Funder: National Institutes of Health

Due Dates: June 17, 2025 (New/Renewal/Resubmission/Revision) | October 15, 2025 | February 13, 2026 | June 15, 2026 | October 15, 2026 | February 17, 2027 | June 15, 2027 | October 15, 2027

Funding Amounts: No budget cap; project period up to 5 years (R61: max 2 years, R33: max 4 years); $27M total NIMH commitment in FY26 for this and companion NOFOs.

Summary: Supports milestone-driven feasibility (R61) and well-powered effectiveness trials (R33) of system-level interventions to improve mental health care delivery and outcomes.

Key Information: Clinical trial required; only system-level interventions (not individual-level) are eligible; foreign and domestic applicants allowed.