Funder: National Institutes of Health

Due Dates: May 24, 2025 (Letter of Intent) | June 23, 2025 (New/Renewal/Resubmission/Revision) | July 17, 2025 (AIDS) | Feb 23, 2026 | Mar 17, 2026 (AIDS) | Oct 20, 2026 | Nov 13, 2026 (AIDS)

Funding Amounts: Up to $1,050,000 in direct costs over 3 years per award; project period not to exceed 3 years.

Summary: Supports early phase clinical trials of natural products (botanicals, dietary supplements, probiotics, standardized nutritional regimens) to replicate target engagement and assess association with clinical outcomes in humans.

Key Information: Efficacy/effectiveness trials and cancer prevention/treatment studies are not supported; strong preliminary data on target engagement in humans is required.