[National Institutes of Health (NIH)](https://www.nih.gov/)

No budget limit; project period up to 5 years; actual award size based on project needs.

Supports research on current topics in Alzheimer’s disease and related dementias, including both basic and clinical studies.

R01 mechanism; clinical trials are optional; standard NIH due dates apply.

--- ## Description This funding opportunity from the NIH invites R01 applications for research on current topics in Alzheimer’s disease (AD) and Alzheimer’s disease-related dementias (ADRD). The program aims to accelerate interdisciplinary research to better understand disease mechanisms, address health disparities, and develop effective interventions. Both basic and clinical research projects are supported, and clinical trials are optional under this announcement. Research priorities will be updated through Notices of Special Interest (NOSIs) published subsequent to this NOFO. Applicants are encouraged to review these notices for evolving high-priority topics. --- ## Due Dates - March 11, 2025 - June 5, 2025 - October 5, 2025 - February 5, 2026 - June 5, 2026 - October 5, 2026 - February 5, 2027 - June 5, 2027 - October 5, 2027 All applications are due by 5:00 PM local time of the applicant organization. NIH standard due dates apply. The opportunity expires November 6, 2027. --- ## Funding Amount - Application budgets are **not limited** but must reflect the actual needs of the proposed project. - Maximum project period: **5 years**. - The number of awards is contingent on NIH appropriations and the submission of a sufficient number of meritorious applications. Applicants requesting **$500,000 or more in direct costs in any year** must contact a Scientific/Research Contact at least 6 weeks before submission. --- ## Eligibility Eligible applicants include: - Public and private institutions of higher education - Nonprofits (with or without 501(c)(3) status) - For-profit organizations (including small businesses) - State, county, city, township, and special district governments - Independent school districts - Public housing authorities/Indian housing authorities - Native American tribal governments (federally recognized and other) - U.S. territories and possessions - Faith-based and community-based organizations - Regional organizations - Non-domestic (non-U.S.) entities (foreign organizations) and components of U.S. organizations Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research is eligible to apply as a Program Director/Principal Investigator (PD/PI). --- ## Application Process - Applications must be submitted electronically via [ASSIST](https://public.era.nih.gov/assist/), Grants.gov Workspace, or an institutional system-to-system solution. - Follow the [NIH Research (R) Instructions](https://grants.nih.gov/grants/how-to-apply-application-guide/forms-h/research-forms-h.pdf) and the specific instructions in the NOFO. - Required registrations: SAM, eRA Commons, Grants.gov, and (for foreign organizations) NCAGE. - All PD(s)/PI(s) must have an eRA Commons account. - If requesting $500,000 or more in direct costs in any year, contact a Scientific/Research Contact at least 6 weeks before submission. **Key components of the application include:** - SF424 (R&R) forms - Research Plan (including Specific Aims and Research Strategy) - Budget (R&R Budget or Modular Budget, as appropriate) - Data Management and Sharing Plan - Human Subjects and/or Vertebrate Animals sections (if applicable) - Letters of Support and Consortium/Contractual Arrangements (if applicable) --- ## Additional Information - Clinical trials are **optional** (applications may or may not propose a clinical trial). - Applicants are encouraged to review [Notices of Special Interest (NOSIs)](https://grants.nih.gov/grants/guide/NOSIs_targetingList.cfm?GuideDocID=42202) for current high-priority research topics. - NIA-funded clinical research must comply with [NIA Clinical Research Operations & Management System (CROMS)](https://croms.nia.nih.gov/resources/resource-list) requirements. - OutreachPro is available for recruitment materials to enhance diversity in clinical research participation. - No cost sharing is required. - Applicant organizations may submit more than one application, provided each is scientifically distinct. --- ## External Links - [Full Funding Opportunity Announcement (PAR-25-332)](https://grants.nih.gov/grants/guide/pa-files/PAR-25-332.html) - [Grants.gov Opportunity Listing](https://www.grants.gov/search-results-detail/357935) - [NIH Standard Due Dates](https://grants.nih.gov/grants/how-to-apply-application-guide/due-dates-and-submission-policies/due-dates.htm) - [How to Apply – NIH Application Guide](https://grants.nih.gov/grants/how-to-apply-application-guide.html) - [Notices of Special Interest (NOSIs)](https://grants.nih.gov/grants/guide/NOSIs_targetingList.cfm?GuideDocID=42202) --- ## Contact Information | Contact Type | Name/Institute | Email | Phone | |-----------------------------|------------------------------------------|--------------------------------------------------|-------------------| | General Grants Info | NIH Grants Information | [GrantsInfo@nih.gov](mailto:GrantsInfo@nih.gov) | 301-480-7075 | | Scientific/Research Contact | Jean Yuan, Ph.D. (NIA) | [jean.yuan@nih.gov](mailto:jean.yuan@nih.gov) | | | Scientific/Research Contact | Frank Paul Shewmaker (NINDS) | [frank.shewmaker@nih.gov](mailto:frank.shewmaker@nih.gov) | 301-496-5680 | | Financial/Grants Mgmt | Philip Smith (NIA) | [philip.smith2@nih.gov](mailto:philip.smith2@nih.gov) | 301-402-3465 | | Financial/Grants Mgmt | Chief Grants Management Officer (NINDS) | [ChiefGrantsManagementOfficer@ninds.nih.gov](mailto:ChiefGrantsManagementOfficer@ninds.nih.gov) | | For technical assistance with ASSIST or eRA Commons, contact the [eRA Service Desk](https://www.era.nih.gov/need-help) or call 301-402-7469 / 866-504-9552. ---

Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01 Clinical Trial Optional)

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