Funder: National Institutes of Health

Due Dates: June 5, 2025 (New) | July 5, 2025 (Renewal/Resubmission) | October 5, 2025 (New) | November 5, 2025 (Renewal/Resubmission) | February 5, 2026 (New) | March 5, 2026 (Renewal/Resubmission) | June 5, 2026 (New) | July 5, 2026 (Renewal/Resubmission) | October 5, 2026 (New) | November 5, 2026 (Renewal/Resubmission)

Funding Amounts: No budget cap; budgets must reflect actual project needs. Maximum project period: 5 years.

Summary: Supports high-risk, multi-center observational studies (not clinical trials) on diseases relevant to NIDDK’s mission; planning activities must be complete before application.

Key Information: Planning activities are not allowed in the application; consult NIDDK staff before applying; clinical trials are not permitted.