Cooperative Agreement for In Vivo High-Resolution Imaging for Inner Ear Visualization (U01 Clinical Trial Required)
This grant aims to fund high-risk clinical trials developing advanced imaging technologies for detailed visualization of the human inner ear in awake patients.
This grant is no longer accepting proposals
National Institutes of Health has archived this opportunity.
Funder: National Institutes of Health
Due Dates: June 3, 2025 | October 1, 2025 | June 3, 2026 | October 1, 2026 (Letter of Intent: 30 days prior to each due date)
Funding Amounts: Up to $500,000 direct costs per year (max 5 years); total program funding ~$3M in FY25 for 2–4 awards (including companion R01)
Summary: Funds high-risk clinical trials to develop advanced in vivo imaging technologies for detailed, non-invasive visualization of the human inner ear in awake patients.
Key Information: Clinical trial is required; only one trial per application; FDA oversight or higher-risk trials only—see eligibility and scope.
Description
This opportunity supports high-risk clinical trials aimed at developing or significantly improving in vivo high-resolution structural and functional imaging technologies for the living human inner ear. The goal is to enable detailed, non-invasive visualization of auditory and vestibular structures (e.g., hair cells, otoliths, membranes, ions, vasculature) in awake patients, advancing both diagnosis and treatment of inner ear disorders.
Projects may focus on:
- Improving the resolution of current imaging modalities (e.g., MRI, micro-CT, OCT, super-resolution microscopy, photoacoustic imaging)
- Developing new imaging techniques, probes, or contrast agents
- Translating imaging technologies into clinical settings, including device development and clinical studies in humans
A multidisciplinary team approach is strongly encouraged. Only clinical trials that require FDA oversight, are intended to establish efficacy, or pose higher risks to participants are eligible. Low-risk trials should apply to the companion R01 (see External Links).
