Funder: Dept. of the Army -- USAMRAA
Due Dates: June 9, 2025 (Pre-Application) | July 21, 2025 (Full Application)
Funding Amounts: Up to $2.5M direct costs per award (max 4 years); ~11 awards; total program funding ~$41.25M
Summary: Supports late-stage preclinical development of medical products (drugs, devices, tools) for clinical use in military-relevant health areas, aiming for regulatory filing or clinical translation.
Key Information: Application is a two-step process (pre-application required); clinical trials are not supported.
Description
This opportunity, offered by the Department of Defense (DoD) through the U.S. Army Medical Research Acquisition Activity (USAMRAA), funds the translation of promising preclinical research into tangible products for clinical application. The focus is on developing interventions—such as drugs, devices, or knowledge products (e.g., clinical decision tools)—that address diseases or conditions relevant to military Service Members, Veterans, and their families. The program expects projects to advance established proof-of-concept or prototypes through the final stages of preclinical development, with the goal of regulatory submission or clinical implementation.
All proposals must address one of the FY25 Peer Reviewed Medical Research Program (PRMRP) topic areas and align with a corresponding strategic goal. The program does not support clinical trials, but does support product development up to the point of regulatory filing or clinical translation.
Due Dates
- Pre-Application (Letter of Intent) Deadline: June 9, 2025, 5:00 p.m. ET
- Full Application Deadline: July 21, 2025, 11:59 p.m. ET
- End of Application Verification Period: July 28, 2025, 5:00 p.m. ET
- Peer Review: September/October 2025
- Programmatic Review: December 2025
Funding Amount
- Total Program Funding: ~$41.25 million
- Expected Number of Awards: ~11
- Maximum Direct Costs per Award: $2.5 million (plus indirects as per negotiated rates)
- Maximum Period of Performance: 4 years
- Awards must be made by: September 30, 2026
- Funds expire for use: September 30, 2031
Eligibility
- Organizations: Open to extramural (academic, non-profit, for-profit, federal agencies other than DoD, research institutes) and intramural DoD organizations (DoD labs, military treatment facilities, etc.), both U.S. and international.
- Principal Investigator: Must be at or above the level of Assistant Professor (or equivalent for industry/other sectors). Each PI may submit only one application (across both TTDA and PRMRP Clinical Trial Award).
- Citizenship: No restrictions; PIs of any nationality may apply if affiliated with an eligible organization.
- Cost Sharing: Not required.
- Other: Awards are made to organizations, not individuals.
Application Process
Step 1: Pre-Application (Letter of Intent)
- Submit via eBRAP.
- Required for all applicants.
- Must specify the PRMRP portfolio, topic area, and strategic goal addressed.
Step 2: Full Application
- Submit via Grants.gov (extramural) or eBRAP (intramural DoD only).
- Must include:
- Project Narrative (18 pages max)
- Supporting Documentation
- Technical and Lay Abstracts
- Statement of Work
- Impact and Military Relevance Statements
- Statistical Plan and Data Analysis
- Post-Award Transition Plan
- Budget and Justification
- Biographical Sketches and Current/Pending Support
- Additional required forms (see full announcement for details)
- Note: Application components exceeding page limits or including unrequested materials will be removed.
Review Process
- Two-tiered: Peer review (technical merit) and programmatic review (relevance to PRMRP priorities and military health).
- No invitation is required to submit a full application after pre-application; applicants are encouraged to prepare both concurrently.
Additional Information
- Scope: Projects must be in the final stages of preclinical development, with established proof-of-concept or prototype and relevant preliminary data.
- Product Types: Tangible (drugs, devices) or knowledge-based (decision tools, guidelines).
- Military Relevance: Proposals must clearly articulate relevance to military health needs.
- Clinical Trials: Not supported under this mechanism.
- Topic Areas & Strategic Goals: Applications must address one of the congressionally mandated FY25 PRMRP topic areas and a corresponding strategic goal. See the full announcement (PDF) for the complete list.
- Collaboration: Multidisciplinary and cross-sector collaborations (academia, industry, DoD, VA) are encouraged.
- Compliance: All applicants must have active registrations in SAM.gov, eBRAP, and Grants.gov.
External Links
Contact Information