Funder: Dept. of the Army -- USAMRAA
Due Dates: June 9, 2025 (Pre-Application/LOI) | July 21, 2025 (Full Application) | July 28, 2025 (End of Verification Period)
Funding Amounts: Up to $8M total costs per award over 4 years; ~4 awards anticipated; total program funding ~$32M.
Summary: Supports rapid implementation of clinical trials (no animal studies) with high impact on treatment/management of diseases in FY25 PRMRP topic areas and strategic goals.
Key Information: Clinical trials are required; all preclinical work must be completed before award start; limited to one application per PI across PRMRP mechanisms.
Description
This opportunity, offered by the U.S. Army Medical Research Acquisition Activity (USAMRAA) under the Peer Reviewed Medical Research Program (PRMRP), funds clinical trials that address congressionally directed FY25 PRMRP topic areas and strategic goals. The intent is to support rapid execution and analysis of clinical trials that could significantly impact the treatment or management of diseases or conditions relevant to military health. Animal studies are not permitted; all preclinical work must be completed prior to the award start date.
Projects may range from small proof-of-concept trials to large-scale comparative effectiveness studies. The program encourages multidisciplinary collaborations, especially those involving military, veteran, or dual-use (military and civilian) populations.
Due Dates
- Pre-Application (Letter of Intent) Deadline: June 9, 2025, 5:00 p.m. ET
- Full Application Deadline: July 21, 2025, 11:59 p.m. ET
- End of Application Verification Period: July 28, 2025, 5:00 p.m. ET
- Peer Review: September/October 2025
- Programmatic Review: December 2025
Funding Amount
- Total Program Funding: ~$32 million
- Number of Awards: Approximately 4
- Maximum Award: Up to $8 million total costs per award (direct + indirect), for up to 4 years
- Funding Instrument: Grant
- Cost Sharing: Not required
Eligibility
- Organizations: Open to extramural (academic, non-profit, for-profit, federal agencies other than DoD, research institutes) and intramural DoD organizations, both U.S. and international.
- Principal Investigator: Must be at or above the level of Assistant Professor (or equivalent for industry/other sectors). Each PI may submit only one application as PI across the FY25 PRMRP Clinical Trial Award and Technology/Therapeutic Development Award.
- Citizenship: No restrictions; individuals of any nationality may be named as PI if affiliated with an eligible organization.
- Other: Awards are made to organizations, not individuals.
Application Process
Step 1: Pre-Application (Letter of Intent)
- Submit via eBRAP.
- Required for all applicants.
- Must specify the PRMRP portfolio, topic area, and strategic goal addressed.
Step 2: Full Application
- Extramural organizations: Submit via Grants.gov.
- Intramural DoD organizations: Submit via eBRAP.
- Full application must include:
- Project Narrative (20-page limit)
- Supporting Documentation (letters of support, facilities, etc.)
- Technical and Lay Abstracts
- Statement of Work
- Study Population Recruitment and Safety Plan
- Data Management and Sharing Plan
- Regulatory Strategy
- Study Personnel and Organization
- Post-Award Transition Plan
- Impact and Relevance to Military Health Statement
- Budget and Justification
- Biographical Sketches and Current/Pending Support for key personnel
Note: All applicants must have active registrations in SAM.gov, eBRAP, and Grants.gov.
Additional Information
- Scope: Only clinical trials are supported; animal studies and preclinical work are not allowed.
- Topic Areas: Applications must address one of the FY25 PRMRP congressionally directed topic areas and one strategic goal. See the full program announcement (PDF) for the complete list of eligible topics and goals.
- Relevance to Military Health: Projects must demonstrate direct relevance to the health of military service members, veterans, and their families.
- Regulatory Requirements: If the trial involves drugs/devices requiring FDA or equivalent oversight, regulatory submissions (e.g., IND/IDE) must be submitted by the full application deadline and approved before award start.
- PI/Organization Limits: Each PI may only submit one application as PI across the PRMRP Clinical Trial and Technology/Therapeutic Development Awards. Multiple applications from the same PI will be administratively withdrawn.
- Review Process: Two-tier review (peer and programmatic) based on scientific merit, relevance to PRMRP priorities, and impact.
External Links
Contact Information