Structure-function Analysis of Vaccines using solid-state Nuclear Magnetic Resonance
This grant aims to improve vaccine manufacturing by developing advanced techniques, like solid-state NMR, to better understand vaccine structure and quality.
This grant is no longer accepting proposals
NRC Research Associateship Programs has archived this opportunity.
Funder: NRC Research Associateship Programs
Due Dates: February 1, 2025 (NIST February review) | May 1, 2025 (Close date) | August 1, 2025 (NIST August review)
Funding Amounts: $82,764 stipend plus $3,000 travel allowance; typical appointment duration 2 years.
Summary: Postdoctoral fellowship to develop and apply solid-state NMR and biophysical techniques for structural characterization of vaccine antigen-adjuvant complexes to improve vaccine manufacturing quality and process understanding.
Key Information: Open to U.S. citizens with a doctoral degree earned within the last 5 years; research conducted on-site at NIST in Gaithersburg, MD; requires prior contact with Research Adviser.
Description
This postdoctoral fellowship opportunity at the National Institute of Standards and Technology (NIST) focuses on advancing vaccine manufacturing by developing analytical technologies based on solid-state nuclear magnetic resonance (ssNMR), time-resolved kinetics, and other biophysical methods. The goal is to address current measurement gaps and improve understanding and control of vaccine product quality and manufacturing processes.
Vaccine products and their manufacturing processes are complex and not fully characterized by existing measurement techniques. Regulatory oversight combined with limited product/process knowledge results in rigid, slow, and costly manufacturing. This fellowship aims to develop and apply advanced structural characterization techniques to antigen-adjuvant complexes—the active pharmaceutical ingredients (APIs) in many vaccines—as well as to individual antigens and adjuvants.
The research will be conducted within the Material Measurement Laboratory, Biomolecular Measurement Division at NIST, located in Gaithersburg, MD.
