Description

This funding opportunity supports high-quality, patient-centered comparative clinical effectiveness research (CER) projects focused on individuals with intellectual and developmental disabilities (IDD). The initiative aims to generate evidence to address meaningful decisional dilemmas faced by patients, clinicians, caregivers, and other stakeholders in healthcare for people with IDD. Projects may compare established or widely used clinical interventions or systems approaches—including pharmacological or non-pharmacological strategies—to improve outcomes related to prevention, screening, diagnosis, treatment, or the dissemination and implementation of evidence-based practices.

For this cycle, PCORI highlights three special areas of emphasis (SAEs): oral health, gastrointestinal (GI) health, and improving care delivery, but applications in other relevant areas are welcome. Interventions must be established, minimally adapted for the IDD population, or in widespread use; proposals to develop or test novel interventions, new technologies, or decision support tools are not eligible. Studies should be well-designed, with a preference for randomized controlled trials or robust observational studies, and are encouraged to use hybrid effectiveness-implementation approaches. Outcomes must be meaningful to patients and stakeholders, and engagement of these groups throughout the research process is required.