Academic-Industrial Partnerships for Translation of Technologies for Diagnosis and Treatment (R01 - Clinical Trial Not Allowed)

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Description

This funding opportunity from the National Institutes of Health (NIH), led by the National Cancer Institute (NCI) and joined by the National Eye Institute (NEI) and National Institute of Dental and Craniofacial Research (NIDCR), aims to stimulate academic-industrial partnerships that translate scientific discoveries and engineering developments into practical methods or tools for disease diagnosis, treatment, and management. The program is designed to bridge gaps between academic and industrial expertise, supporting interdisciplinary, multi-institutional teams to develop, adapt, optimize, and validate technologies for end-user application in pre-clinical, clinical, or non-clinical settings.

Projects must focus on translational research—moving a technology, method, assay, device, or system from proof-of-concept to a state ready for use in the intended setting. The definition of "innovation" for this opportunity is broad, emphasizing the likelihood of delivering a new capability to end users, including in low-resource or underserved settings.

Clinical trials are not allowed under this opportunity.

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Due Dates

• Standard NIH R01 due dates apply:
  • New Applications: June 5, October 5, February 5 (annually)
  • Renewal/Resubmission/Revision: July 5, November 5, March 5 (annually)
• These cycles repeat through November 2027.
• All applications are due by 5:00 PM local time of the applicant organization.
• The opportunity expires January 8, 2028.

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Funding Amount

• Maximum direct costs: $499,000 per year
• Project period: Up to 5 years
• Award mechanism: R01 (Research Project Grant)
• No cost sharing required
• Number of awards: Contingent on NIH appropriations and the number of meritorious applications

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Eligibility

• Eligible organizations include:

  • Public and private institutions of higher education
  • Nonprofits (with or without 501(c)(3) status)
  • For-profit organizations (including small businesses)
  • State, county, city, township, and special district governments
  • Native American tribal governments and organizations
  • Independent school districts
  • Public housing authorities/Indian housing authorities
  • Faith-based and community-based organizations
  • Regional organizations
  • U.S. territories and possessions
  • Non-domestic (non-U.S.) entities (foreign organizations)
  • Eligible agencies of the federal government

• Key requirements:

  • Each application must include at least one academic and one industrial partner.
  • Multi-institutional, interdisciplinary teams are encouraged.
  • Foreign organizations and components are eligible to apply.

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Application Process

• Submission: Electronic submission via Grants.gov, NIH ASSIST, or institutional system-to-system solutions.

• Required registrations: SAM, eRA Commons, Grants.gov, and (for foreign organizations) NCAGE code.

• Application format: Follow the NIH SF424 (R&R) Application Guide and the specific instructions in the funding announcement.

• Key application components:

  • Specific Aims
  • Research Strategy (including significance, innovation, approach, and partnership structure)
  • Budget and justification
  • Data Management and Sharing Plan
  • Resource Sharing Plan
  • Letters of support from all partners
  • Biosketches for key personnel

• Review criteria: Scientific significance, innovation (as defined by likelihood to deliver new capability), rigor and feasibility, expertise and resources, and partnership structure.

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Additional Information

• Scope: Projects must focus on translation, not basic research or commercial production. Applications that do not emphasize adaptation, optimization, and validation for a targeted research or clinical problem are not responsive.
• Examples of supported activities: Development and validation of diagnostic/imaging systems, harmonization of data across platforms, creation of shared resources or data archives, adaptation of technologies for low-resource settings, and integration of AI/machine learning for clinical or research use.
• IC-specific interests: NCI is interested in cancer diagnostics, immunological monitoring, point-of-care tools, and next-generation platforms. NEI seeks projects aligned with its strategic plan for vision research. ORWH is interested in projects relevant to women's health.
• Data sharing: All applications must include a Data Management and Sharing Plan in accordance with NIH policy.
• No clinical trials: Applications proposing clinical trials will not be accepted.

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External Links

• NIH Funding Opportunity Announcement (PAR-25-338)
• NIH Application Guide (Forms-H)
• NIH Grants & Funding Main Page
• Grants.gov Opportunity Listing
• NCI Strategic Plan
• NEI Strategic Plan
• NIH Data Management and Sharing Policy

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Contact Information

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