Addressing Health Outcomes for Individuals With Intellectual and Developmental Disabilities (IDD) and/or Rare Diseases (RD) PCORI Funding Announcement -- Cycle 3 2026
PCORI’s 2026 funding supports comparative effectiveness research to improve health outcomes for individuals with intellectual and developmental disabilities and/or rare diseases.
Funder: Patient-Centered Outcomes Research Institute
Due Dates: September 9, 2026 (Letter of Intent) | January 12, 2027 (Full Application)
Funding Amounts: Up to $12 million direct costs per award; project duration up to 5 years; total program budget up to $60 million.
Summary: Supports high-impact, patient-centered comparative effectiveness research to improve health outcomes for individuals with intellectual and developmental disabilities (IDD) and/or rare diseases (RD).
Key Information: LOI required for invitation to apply; individuals may not apply directly—organizational applicants only.
Description
This funding opportunity from the Patient-Centered Outcomes Research Institute (PCORI) seeks rigorous, patient-centered comparative clinical effectiveness research (CER) focused on improving the health outcomes of people living with intellectual and developmental disabilities (IDD) and/or rare diseases (RD). The program emphasizes addressing significant evidence gaps and decisional dilemmas in healthcare for these populations, including challenges in diagnosis, care access, care transitions, and both pharmacologic and nonpharmacologic interventions. Proposals should compare established or widely used interventions, delivery models, or system-level strategies, and must incorporate meaningful engagement of patients, caregivers, and other stakeholders throughout the research process. Studies may focus on either IDD or RD, or both, and may include research addressing patient and/or caregiver outcomes.
