Addressing Health Outcomes for Individuals With Intellectual and Developmental Disabilities (IDD) and/or Rare Diseases (RD) PCORI Funding Announcement - Cycle 3 2026
Addressing Health Outcomes for Individuals With IDD and/or RD supports researchers comparing clinical care strategies to improve health outcomes for people with these conditions and their caregivers.
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Funder: Patient-Centered Outcomes Research Institute
Due Dates: September 9, 2026, 5 pm ET (LOI) | October 14, 2026 (LOI notification) | January 12, 2027, 5 pm ET (Application)
Funding Amounts: Up to $12 million in direct costs per project over five years; approximately $60 million available
Summary: Supports patient-centered comparative clinical effectiveness research improving health outcomes for people with IDD and/or rare diseases and their caregivers.
Key Information: Full applications require an accepted LOI and invitation from PCORI; individuals cannot apply.
Description
PCORI funds high-impact, patient-centered comparative clinical effectiveness research (CER) addressing evidence gaps and healthcare decisions for people with intellectual and developmental disabilities (IDD) and/or rare diseases (RD). Studies compare at least two clinical interventions or care delivery strategies with established efficacy or widespread use, assessing benefits and harms in real-world settings. Research may address diagnosis, treatment, care coordination or caregiver health.
The initiative seeks evidence that helps patients, caregivers, clinicians and health systems make informed decisions across the lifespan. Priorities include access to patient-centered care, transitions between settings and pediatric-to-adult services, physical and mental health treatments, and caregiver well-being. Studies may focus on one condition or cross-cutting issues across diagnoses. Addressing both IDD and RD, or a Special Area of Emphasis, provides no competitive advantage.
