Funder: Patient-Centered Outcomes Research Institute
Due Dates: September 9, 2026, 5 p.m. ET (LOI) | January 12, 2027, 5 p.m. ET (Invited application)
Funding Amounts: Up to $12 million in direct costs for up to five years; approximately $60 million available
Summary: Supports patient-centered comparative clinical effectiveness research improving outcomes for people with intellectual and developmental disabilities and/or rare diseases and caregivers.
Key Information: Full applications require an accepted LOI and invitation from PCORI; individuals cannot apply.
Description
The Patient-Centered Outcomes Research Institute (PCORI) funds high-impact, patient-centered comparative clinical effectiveness research (CER) addressing evidence gaps for people with intellectual and developmental disabilities (IDD) and/or rare diseases (RD). Studies must compare at least two healthcare options with evidence of efficacy or widespread use, generating evidence to help patients, caregivers and healthcare professionals make informed decisions.
Special Areas of Emphasis include access to patient-centered care, transitions across care settings and the lifespan, pharmacologic and nonpharmacologic approaches to physical and mental health, and caregiver health and well-being. Studies may address one condition or cross-cutting issues across diagnoses. Addressing both IDD and RD, or an emphasis area, offers no competitive advantage. Patients and healthcare partners must contribute meaningfully throughout the research.
