Addressing Health Outcomes for Individuals With Intellectual and Developmental Disabilities (IDD) and/or Rare Diseases (RD) PCORI Funding Announcement
PCORI funds research to improve health outcomes for people with intellectual and developmental disabilities and/or rare diseases through patient-centered comparative effectiveness studies.
Funder: Patient-Centered Outcomes Research Institute
Due Dates: September 9, 2026 (Letter of Intent) | January 12, 2027 (Application)
Funding Amounts: Up to $12 million direct costs per project | Up to 5 years per project | Total initiative up to ~$60 million
Summary: Supports high-impact, patient-centered comparative effectiveness research to improve health outcomes for individuals with intellectual and developmental disabilities and/or rare diseases.
Key Information: LOI required; only invited applicants may submit full proposals.
Description
The Patient-Centered Outcomes Research Institute (PCORI) is inviting applications for patient-centered comparative clinical effectiveness research (CER) projects that address health outcomes for individuals with intellectual and developmental disabilities (IDD) and/or rare diseases (RD). This initiative aims to fill critical evidence gaps and help patients, caregivers, and clinicians make informed healthcare decisions. Research proposals may focus on either IDD, RD, or both, and should prioritize outcomes that matter to patients and caregivers, using robust study designs to generate actionable evidence.
PCORI encourages studies addressing challenges in access to care, care transitions, evaluation of interventions (pharmacologic or nonpharmacologic), and caregiver well-being. Proposals should include meaningful patient and stakeholder engagement throughout the research process.
