Cycle 2 2025 Addressing Violence and Trauma Topical PCORI Funding Announcement
PCORI funds large-scale patient-centered research comparing established interventions for violence and trauma, including intentional and unintentional trauma and substance use, to generate actionable evidence for healthcare practice.
Funder: Patient-Centered Outcomes Research Institute
Due Dates (Anticipated): May 2026 (Letter of Intent) | September 2026 (Full application)
Funding Amounts: Up to $12 million direct costs per project (max 5 years); total funding available: ~$60 million
Summary: Funds large-scale, patient-centered comparative effectiveness research to address violence and trauma, focusing on intentional trauma, unintentional trauma, and substance use.
Key Information: Two-stage process: LOI required before full application; individuals may not apply.
Description
This funding opportunity from the Patient-Centered Outcomes Research Institute (PCORI) supports high-quality, patient-centered comparative clinical effectiveness research (CER) projects that address violence and trauma. The announcement targets three Special Areas of Emphasis: (1) intentional trauma (including intimate partner violence, abuse of children and youth, and abuse of older adults), (2) unintentional trauma (such as traumatic brain injury, fall prevention and recovery among older adults, and impaired mobility due to unintentional trauma), and (3) substance use and trauma (with a focus on pain management strategies to reduce susceptibility to substance use disorder after traumatic injury).
Projects must compare at least two established interventions, focus on patient-centered outcomes, and actively engage patients and stakeholders throughout the research process. The research should address real-world decisional dilemmas, fill critical evidence gaps identified by stakeholders, and generate actionable evidence to inform clinical practice and healthcare delivery.
