[European Commission](https://commission.europa.eu/index_en)

September 18, 2025 (single-stage)

€8,000,000–€10,000,000 per project | Approx. 4 projects funded

Grant supporting innovative use of generative AI to develop digital twins for complex systems, advancing European research infrastructures and enabling new applications across key sectors.

Proposals must address at least three application scenarios and demonstrate interdisciplinary impact.

--- ## Description This Horizon Europe call aims to fund projects that leverage generative artificial intelligence (AI) to create digital twins of complex real-world systems, with the goal of advancing the capabilities of European research infrastructures. The focus is on demonstrating innovative applications of AI—aligned with the GenAI4EU initiative and other EU strategies—to enable highly complex modelling and simulation activities. Projects should establish best practices for model generation, simulation, and data fusion, and foster new applications relevant to sectors such as healthcare, transportation, agriculture, environment, manufacturing, or other areas tied to the Clean Industrial Deal. Solutions must be demonstrated across at least three distinct application scenarios and should empower non-technical decision-makers to use simulations for impactful decision-making. Proposals should also address transparency and trustworthiness in AI use, contribute to European AI Factories, and show applicability across multiple scientific domains. --- ## Due Dates - Opening date: May 6, 2025 - Submission deadline: September 18, 2025, 17:00 Brussels time --- ## Funding Amount - Total available budget for this topic: €40,000,000 - Expected contribution per project: €8,000,000–€10,000,000 (lump sum) - Indicative number of projects funded: 4 --- ## Eligibility - Open to legal entities (public or private) established in EU Member States or Horizon Europe Associated Countries. - Proposals must include participants from at least three eligible countries. - Additional eligibility details, including participation of non-EU/non-Associated Countries, are available in [Annex B of the Work Programme General Annexes](https://ec.europa.eu/info/funding-tenders/opportunities/docs/2021-2027/horizon/wp-call/2025/wp-14-general-annexes_horizon-2025_en.pdf). - Subject to standard Horizon Europe admissibility, financial, and operational capacity checks. --- ## Application Process - Single-stage submission via the [EU Funding & Tenders Portal](https://ec.europa.eu/info/funding-tenders/opportunities/portal/screen/opportunities/topic-details/HORIZON-INFRA-2025-01-TECH-04?isExactMatch=true&status=31094501,31094502&order=DESC&pageNumber=11&pageSize=50&sortBy=startDate). - Use the standard application form for Horizon Europe Research and Innovation Actions (RIA). - Proposals must address all aspects listed in the call, including demonstration of AI-driven digital twins in at least three scenarios and coverage of multiple scientific domains. - Guidance, templates, and evaluation criteria are provided in the [HE Programme Guide](https://ec.europa.eu/info/funding-tenders/opportunities/docs/2021-2027/horizon/guidance/programme-guide_horizon_en.pdf) and [General Annexes](https://ec.europa.eu/info/funding-tenders/opportunities/docs/2021-2027/horizon/wp-call/2025/wp-14-general-annexes_horizon-2025_en.pdf). --- ## Additional Information - Eligible costs are funded as a lump sum. - Proposals in Earth system digital twins must comply with standards from the [Destination Earth initiative](https://digital-strategy.ec.europa.eu/en/policies/destination-earth). - Proposals should align with the [GenAI4EU initiative](https://digital-strategy.ec.europa.eu/en/policies/ai-factories) and may benefit from synergies with other European AI and ICT infrastructures (e.g., EuroHPC, AI-on-demand platform). - Projects in energy-intensive industrial transition are encouraged to coordinate with the European Commission’s Joint Research Centre (JRC). --- ## External Links - [Call Details & Submission Portal](https://ec.europa.eu/info/funding-tenders/opportunities/portal/screen/opportunities/topic-details/HORIZON-INFRA-2025-01-TECH-04?isExactMatch=true&status=31094501,31094502&order=DESC&pageNumber=11&pageSize=50&sortBy=startDate) - [Horizon Europe Programme Guide](https://ec.europa.eu/info/funding-tenders/opportunities/docs/2021-2027/horizon/guidance/programme-guide_horizon_en.pdf) - [General Annexes 2025](https://ec.europa.eu/info/funding-tenders/opportunities/docs/2021-2027/horizon/wp-call/2025/wp-14-general-annexes_horizon-2025_en.pdf) - [Application Form Template (HE RIA, IA)](https://ec.europa.eu/info/funding-tenders/opportunities/docs/2021-2027/horizon/temp-form/af/af_he-ria-ia_en.pdf) - [AI Factories Policy](https://digital-strategy.ec.europa.eu/en/policies/ai-factories) - [Destination Earth Policy](https://digital-strategy.ec.europa.eu/en/policies/destination-earth) --- ## Contact Information | Purpose | Contact / Link | |----------------------------|-----------------------------------------------------------------------------------------------| | General EC Contact | [Contact the European Commission](https://commission.europa.eu/about-european-commission/contact_en) | | Research Enquiry Service | [Research Enquiry Service](https://research-and-innovation.ec.europa.eu/contact-us/research-enquiry-service_en) | | National Contact Points | [Find National Contact Points](https://ec.europa.eu/info/funding-tenders/opportunities/portal/screen/support/ncp) | | IT Helpdesk | [Funding & Tenders Portal IT Helpdesk](https://ec.europa.eu/info/funding-tenders/opportunities/portal/screen/support/helpdesks/contact-form) |

AI-generated digital twins for science

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