[Alzheimer's Drug Discovery Foundation](https://www.alzdiscovery.org)

January 12, 2026 (Invited full proposal) | September 14, 2026 (Letter of Intent)

Up to $5,000,000 per project; multi-year support; direct costs only.

Supports IND-enabling studies and early-phase clinical trials of novel drugs and devices for Alzheimer’s disease and related dementias.

Anti-amyloid and cholinesterase inhibitor approaches are excluded.

--- ## Description This opportunity funds investigational new drug (IND)-enabling studies and early-phase clinical trials for promising pharmacological interventions and devices targeting Alzheimer’s disease and related dementias. The program emphasizes diverse drug mechanisms, especially those connected to the biology of aging and emerging therapeutic areas. Priority is given to combination therapies, disease-modifying and symptomatic agents, and novel, repurposed, or repositioned drugs and devices. Proposals should present robust preclinical and clinical data, biomarker-based proof-of-concept studies, and clear rationales for the targeted mechanisms. Collaborative, multidisciplinary teams are encouraged. All funded clinical trials must be registered and results submitted to ClinicalTrials.gov. --- ## Due Dates - January 12, 2026: Invited full proposal deadline - September 14, 2026: Letter of Intent deadline --- ## Funding Amount - Maximum award: Up to $5,000,000 per project, depending on stage and scope. - Typical duration: Multi-year (project length based on proposal). - Only direct costs are allowed (no indirect/overhead). - Co-funding from other agencies or investors is encouraged for larger studies. - Payment is milestone-based and negotiated per project. --- ## Eligibility - Open to researchers and clinicians worldwide. - Eligible organizations: - Academic medical centers, universities, and nonprofit research institutions - Biotechnology companies (including startups) - Industry partnerships are strongly encouraged. - Restrictions: - Only one LOI and one invited full proposal per applicant per cycle (biotech companies are limited to one per cycle). - No restrictions by career stage. - Excluded: Projects focused on anti-amyloid or cholinesterase inhibitor approaches, or non-pharmacologic interventions (e.g., diet, meditation, exercise). --- ## Application Process - **Step 1: Letter of Intent (LOI)** - Submit via the [ADDF Funding Portal](https://addf.fluxx.io/) - Brief descriptions: scientific rationale, specific aims, key supporting data (300 words each) - Notification within 2–3 weeks of LOI deadline - **Step 2: Invited Full Proposal** - Only after LOI approval - Submit via the [ADDF Funding Portal](https://addf.fluxx.io/) - Requires detailed project narrative, budget, biosketches, and (for biotech) business packet - Notification within 3–4 months of full proposal deadline - **Required Documents:** - Project narrative (background, supporting data, objectives, methods, team, IP, other support, references) - Budget (Excel template, justification, direct costs only) - Biosketches for all key personnel (NIH format preferred) - Business packet (for biotech companies) - Supplemental materials (optional: protocols, vendor quotes, letters of support) - **Note:** All clinical trials must be registered and results submitted to ClinicalTrials.gov. --- ## Additional Information - Funding is provided as mission-related investments (MRI) with return on investment based on milestones. - Only direct costs are allowed (no indirects, capital equipment, or overhead). - Applicants may resubmit proposals up to two times if reviewer concerns are addressed. - For follow-on funding, contact ADDF scientific staff three months before project end. --- ## External Links - [Drug Development RFP Details](https://www.alzdiscovery.org/research-and-grants/funding-opportunities/drug-development-rfp) - [Application Instructions](https://www.alzdiscovery.org/research-and-grants/funding-opportunities/application-instructions) - [Funding Policies](https://www.alzdiscovery.org/research-and-grants/funding-opportunities/policies) - [ADDF Funding Portal (Apply/Login)](https://addf.fluxx.io/) - [Our Research Strategy](https://www.alzdiscovery.org/research-and-grants/our-research-strategy) --- ## Contact Information | Contact | Email | Phone | Online Form | |------------------------|-----------------------------|---------------|--------------------------------------------------------| | ADDF Grants & Mission-Related Investments Team | grants@alzdiscovery.org | 212.901.8000 | [Contact Us](https://www.alzdiscovery.org/contact-us) |

Drug Development RFP

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