American Cancer Society and Flatiron Clinical Trials Technology Research Impact Award (CTTRIA)

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Description

This opportunity, jointly offered by the American Cancer Society (ACS) and Flatiron, aims to accelerate cancer research by supporting projects that implement, utilize, or study the impact of technology to advance the conduct of cancer clinical trials. The focus is on improving access, representativeness, and efficiency in clinical trials, with a particular emphasis on the use of interoperable technology for data capture and transfer.

Projects must incorporate the use of Flatiron Clinical PipeTM, an EHR-to-EDC (Electronic Health Record to Electronic Data Collection) solution, to transfer study data for one or more cancer clinical trials. The grant does not fund the clinical trials themselves, but rather research on the impact of technology on trial conduct. Special consideration is given to multi-institutional projects at sites that do not currently have Flatiron Clinical PipeTM installed; Flatiron will assist with installation if needed.

Example research topics include:

• Impact of electronic data transfer on research staff effort, data entry time, productivity, and satisfaction
• Effects of EHR-to-EDC technology on data quality, timeliness, accuracy, and completeness
• Modeling technology’s impact on study timelines and costs
• Feasibility of deploying EHR-to-EDC software in multi-institutional trials
• Change management for migration from paper to electronic workflows

The ultimate goal is to improve the evaluation of new treatments, increase patient access to studies, and promote better health outcomes.

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Due Dates

• Informational Webinar: March 3, 2025, 2:00–3:00 PM EST (register here)
• Letter of Intent (LOI) Deadline: March 17, 2025, 11:59 PM EDT
• Invitation to Apply Notification: By April 1, 2025
• Full Application Deadline: June 1, 2025, 11:59 PM EDT
• Peer Review: August–September 2025
• Award Notification: October 2025
• Anticipated Grant Start: January 2026

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Funding Amount

• Total Award: $250,000 (direct costs only)
• Duration: 2 years
• Indirect Costs: Not allowed
• Number of Awards: 1

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Eligibility

• Eligible Applicants: Independent researchers at eligible academic institutions or nonprofits in the United States
• Citizenship: United States
• Applicant Requirements: Sufficient training and expertise to conduct the proposed research
• Institutional Requirements: Must be able to contract with ACS and comply with Flatiron’s confidentiality agreement
• Special Consideration: Multi-institutional projects at sites without Flatiron Clinical PipeTM installed

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Application Process

Step 1: Letter of Intent (LOI)

• Deadline: March 17, 2025
• Submission: Via ProposalCentral
• Required Materials:
  • PI biosketch (max 5 pages, NIH or provided template)
  • Project description (max 3 pages/10,000 characters): background, aims, research plan, significance
  • Extent of involvement with Clinical PipeTM (max 1 page/3,000 characters): current/planned use, questions/issues
• Review: LOIs are assessed for feasibility and fit; feedback provided by April 1, 2025

Step 2: Full Application

• By invitation only (after LOI approval)
• Deadline: June 1, 2025
• Submission: ProposalCentral
• Review: Peer review in August–September 2025

Additional Notes

• If the deadline falls on a weekend or holiday, applications are accepted the next business day.
• Awarded institutions will contract with ACS and must comply with Flatiron’s confidentiality agreement.

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Additional Information

• Flatiron Clinical PipeTM is required for all projects; Flatiron will assist with installation if needed.
• The grant does not fund the clinical trials themselves, but research on technology’s impact on trial conduct.
• Only one award will be made in this cycle.

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External Links

• ACS CTTRIA Grant Details (Official Page)
• ACS Grant Process Overview
• ProposalCentral (Application Portal)
• LOI Submission Instructions (PDF)
• Watch Informational Webinar

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Contact Information