NFRP Outreach and Invitation for Response
The US Army seeks feedback on a potential research agreement (rOTA) for clinical trials of therapies for neurofibromatosis (NF1, NF2, schwannomatosis), requiring cost-sharing and industry partnership.
Funder: Dept. of the Army -- USAMRAA
Due Dates: Forecasted; no formal deadline—currently requesting feedback on approach
Funding Amounts: Award size and total funding not specified; cost sharing required; milestone-based payments anticipated
Summary: The Army seeks feedback from research teams on a potential agreement to accelerate clinical trials of therapies for neurofibromatosis (NF1, NF2, schwannomatosis), with requirements for cost sharing and industry partnership.
Key Information: This is not a solicitation; responses are for planning and feedback only, not formal proposals.
Description
The Congressionally Directed Medical Research Program (CDMRP) Neurofibromatosis Research Program (NFRP), in partnership with the US Army Medical Research Acquisition Activity (USAMRAA), is exploring the establishment of a Research-based Other Transactions Agreement (rOTA) to support a major, product-driven team of institutions and investigators. The goal is to accelerate the clinical translation of basic research into therapies for neurofibromatosis types 1 and 2 (NF1, NF2) and schwannomatosis, ultimately reducing the impact of these diseases.
This outreach is a request for feedback on the proposed approach and capabilities for a future rOTA, not a formal funding opportunity or solicitation. The envisioned rOTA would support collaborative Phase I and II clinical trials of promising therapeutic agents for NF1, NF2, and schwannomatosis, involving a single Operations Center and at least five Clinical Trial Sites with a strong record of collaborative research.
Key features include cost sharing, potential requirements for industry partnership, milestone-based payments, and the need to demonstrate access to relevant patient populations.
