BioStabilization Systems (BoSS)
BioStabilization Systems (BoSS) supports teams developing room-temperature preservation technologies for cells and biologics to reduce cold-chain dependence and expand access to advanced medicines.
This grant was recently updated
ARPA-H has replaced the BoSS solicitation and application deadlines with an awardees section announcing selected research teams. Application links, Proposers’ Day materials, and teaming resources were removed from the program page, and the BoSS FAQ page now returns “Page not found.”
Funder: Advanced Research Projects Agency for Health
Due Dates: Not listed
Funding Amounts: Not listed
Summary: BoSS supports technologies for room-temperature preservation of cells and biologics to reduce cold-chain dependence and expand access to advanced medicines.
Description
BioStabilization Systems (BoSS), a program of the Advanced Research Projects Agency for Health (ARPA-H), aims to develop technologies to produce, store, and ship cells at room temperature without refrigeration. It addresses the fragility of biologics—treatments made with cells, genes, and complex proteins—whose dependence on an uninterrupted ultra-cold supply chain raises costs, risks product losses, and limits patient access.
The program seeks to combine approaches inspired by nature and materials science to achieve long-term shelf-life stability for cell therapies and biologics. These include adapting survival strategies from organisms that withstand extreme conditions, using protective molecules and advanced materials. Its goals include more resilient manufacturing and distribution, reduced costs and losses, broader access in remote and resource-limited communities, and faster crisis response through the ability to stockpile biologics.
