BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Basic Experimental Studies with Humans Required)
This grant funds exploratory, multidisciplinary research using invasive neural recording and stimulation in humans to investigate how brain activity produces sensations, thoughts, emotions, and behaviors.
Funder: National Institutes of Health
Due Dates: February 11, 2027 (Full application deadline)
Funding Amounts: Up to $700,000 per award; total program funding estimated at $6,000,000; ~5 awards expected.
Summary: Supports exploratory research and planning activities using invasive neural recording and stimulation technologies in the human brain to advance understanding of human brain function.
Description
This grant opportunity supports exploratory research projects that leverage invasive surgical procedures in humans to record and stimulate neuronal activity within localized brain structures. The aim is to enable high-impact neuroscience investigations into how dynamic activity of single cells and neural ensembles in spatially organized networks leads to sensations, perceptions, emotions, thoughts, memories, and observable behaviors. Projects should focus on feasibility and early-stage development, laying the groundwork for future research grant applications involving invasive neural recording and stimulation technologies in humans. Funded teams will participate in a consortium working group coordinated by NIH to establish consensus standards, address neuroethical considerations, and facilitate data aggregation and sharing with the broader scientific community.
