BRAIN Initiative: Preclinical Proof of Concept for Novel Recording and Modulation Technologies in the Human CNS (R18 - Clinical Trial Not Allowed)
Develop innovative recording and modulation technologies for treating CNS disorders, advancing from proof-of-concept to human studies, welcoming diverse expertise collaborations.
Funder: National Institutes of Health
Due Dates: May 29, 2024 (Application) | January 28, 2025 (Application) | September 29, 2025 (Application) | May 28, 2026 (Application) | January 28, 2027 (Application)
Funding Amounts: Up to $750,000 direct costs per year; project period up to 3 years; estimated $8M total to fund 5–7 awards.
Summary: Supports preclinical proof-of-concept and development of innovative CNS recording/modulation technologies advancing toward first-in-human readiness.
Key Information: Clinical trials are not allowed; applications missing required attachments will be withdrawn.
Description
This opportunity supports the translation of novel technologies for recording and modulating the human central nervous system (CNS), from proof-of-concept through preclinical development, with the goal of achieving readiness for first-in-human (FIH) studies. Technologies may use any signal modality (electrical, optical, magnetic, acoustic, or combinations), and can be non-invasive, minimally invasive, implantable, or hybrid. The program emphasizes team-based, multidisciplinary approaches and requires design-driven development, integration of stakeholder needs, and rigorous preclinical validation.
Proposals must focus on technology development (not hypothesis-driven research) and demonstrate a credible path to human application within five years. The initiative encourages cross-disciplinary collaboration and requires applicants to provide clear project management plans, regulatory pathways, and quantitative milestones.
