Description

This funding opportunity supports the optimization of instrumentation and device technologies for recording and modulation of neural cells and circuits in the central nervous system (CNS). The goal is to overcome major experimental barriers and enable transformative advances in understanding dynamic neural signaling. Applications should focus on technologies that have already demonstrated transformative potential in proof-of-concept testing and are ready for accelerated refinement through iterative engineering and end-user feedback.

Projects may include the development of hardware, devices, and associated software for modalities such as optical, electrical, magnetic, or acoustic recording/manipulation, targeting neuronal electrical signals or other forms of neural activity. The approaches must be compatible with experiments in behaving animals and validated in vivo. The primary focus should be on demonstrating the capabilities and impact of the technology, rather than advancing biological knowledge per se.

This opportunity is part of the NIH BRAIN Initiative and is a re-issue with a narrowed focus on instrumentation and devices, excluding projects primarily focused on molecular reagent development.